中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
14-3-3 Binding to Cyclin Y contributes to cyclin Y/CDK14 association

文献类型:期刊论文

作者Li, S; Jiang, M; Wang, WJ; Chen, JY
刊名ACTA BIOCHIMICA ET BIOPHYSICA SINICA
出版日期2014
卷号46期号:4页码:299-304
关键词cyclin Y 14-3-3 protein 14-3-3 binding motif
通讯作者Chen, JY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,jychen@sibcb.ac.cn
英文摘要Cyclin Y is a highly conserved cyclin among eumetazoans, yet its function and regulation are poorly understood. To search for Cyclin Y-interacting proteins, we screened a yeast two-hybrid library using human Cyclin Y (CCNY) as a bait and identified the following interactors: CDK14 and four members of the 14-3-3 family (epsilon, beta, eta, tau). The interaction between CCNY and 14-3-3 proteins was confirmed both in vitro and in vivo. The results showed that Ser-100 and Ser-326 residues in CCNY were crucial for 14-3-3 binding. Interestingly, binding of CCNY to 14-3-3 significantly enhanced the association between CCNY and CDK14. Our findings may add a new layer of regulation of CCNY binding to its kinase partner.
学科主题Biochemistry & Molecular Biology; Biophysics
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]CONSERVED CYCLIN ; IN-VIVO ; PROTEINS ; KINASE ; 14-3-3-PROTEINS ; PHOSPHORYLATION ; ACTIVATION ; DOMAINS ; CRK1 ; FORM
收录类别SCI
语种英语
WOS记录号WOS:000334023100006
版本出版稿
源URL[http://202.127.25.143/handle/331003/178]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
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GB/T 7714
Li, S,Jiang, M,Wang, WJ,et al. 14-3-3 Binding to Cyclin Y contributes to cyclin Y/CDK14 association[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2014,46(4):299-304.
APA Li, S,Jiang, M,Wang, WJ,&Chen, JY.(2014).14-3-3 Binding to Cyclin Y contributes to cyclin Y/CDK14 association.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,46(4),299-304.
MLA Li, S,et al."14-3-3 Binding to Cyclin Y contributes to cyclin Y/CDK14 association".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 46.4(2014):299-304.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

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