Mll2 Controls Cardiac Lineage Differentiation of Mouse Embryonic Stem Cells by Promoting H3K4me3 Deposition at Cardiac-Specific Genes
文献类型：期刊论文
| 作者 | Wan, XL; Liu, LL; Ding, XD; Zhou, PP; Yuan, XJ; Zhou, ZW; Hu, P; Zhou, H; Li, Q; Zhang, SH |
| 刊名 | STEM CELL REVIEWS AND REPORTS
 |
| 出版日期 | 2014 |
| 卷号 | 10期号:5页码:643-652 |
| 关键词 | Histone methylation Cardiac differentiation Embryonic stem cells |
| 通讯作者 | Xiong, SD (reprint author), Soochow Univ, Inst Biol & Med Sci, 199 Renai Rd, Nanjing 215123, Jiangsu, Peoples R China.,sdxiong@suda.edu.cn ; yan_zhang@sibs.ac.cn |
| 英文摘要 | Trithorax group (TrxG) proteins play critical roles in transcriptional activation by promoting methylation of histone H3 Lysine 4 (H3K4), but the precise functions of the individual TrxG members during embryonic differentiation are not fully understood. Here we show that Mll2, a TrxG member, is required for proliferation but is dispensable for maintaining the pluripotency of mouse embryonic stem cells (ESCs). In addition, differentiation of ESCs toward mesodermal and endodermal lineages is severely altered and, in particular, the cardiac lineage differentiation of ESCs is completely abolished in the absence of Mll2. Moreover, the expression of core cardiac transcription factors and the levels of H3K4 tri-methylation of these cardiac-specific promoters are significantly decreased by the loss of Mll2. Taken together, our results reveal a critical role for Mll2 in proliferation and cardiac lineage differentiation of mouse ESCs, and provide novel molecular insight into the mechanisms of cardiac development and disease. |
| 学科主题 | Cell Biology; Research & Experimental Medicine |
| 类目[WOS] | Cell & Tissue Engineering ; Cell Biology ; Medicine, Research & Experimental |
| 关键词[WOS] | HISTONE ; MECHANISMS ; EXPRESSION ; TRITHORAX ; GENOME ; PLURIPOTENCY ; DEMETHYLASES ; LANDSCAPE ; PROTEINS ; LEUKEMIA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000342214700003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/185]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wan, XL,Liu, LL,Ding, XD,et al. Mll2 Controls Cardiac Lineage Differentiation of Mouse Embryonic Stem Cells by Promoting H3K4me3 Deposition at Cardiac-Specific Genes[J]. STEM CELL REVIEWS AND REPORTS,2014,10(5):643-652. |
| APA | Wan, XL.,Liu, LL.,Ding, XD.,Zhou, PP.,Yuan, XJ.,...&Zhang, Y.(2014).Mll2 Controls Cardiac Lineage Differentiation of Mouse Embryonic Stem Cells by Promoting H3K4me3 Deposition at Cardiac-Specific Genes.STEM CELL REVIEWS AND REPORTS,10(5),643-652. |
| MLA | Wan, XL,et al."Mll2 Controls Cardiac Lineage Differentiation of Mouse Embryonic Stem Cells by Promoting H3K4me3 Deposition at Cardiac-Specific Genes".STEM CELL REVIEWS AND REPORTS 10.5(2014):643-652. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。