Dynamic Interactions between TIP60 and p300 Regulate FOXP3 Function through a Structural Switch Defined by a Single Lysine on TIP60
文献类型：期刊论文
| 作者 | Xiao, Y; Nagai, Y; Deng, GP; Ohtani, T; Zhu, ZQ; Zhou, ZC; Zhang, HT; Ji, MQ; Lough, JW; Samanta, A |
| 刊名 | CELL REPORTS
 |
| 出版日期 | 2014 |
| 卷号 | 7期号:5页码:1471-1480 |
| 通讯作者 | Greene, MI (reprint author), Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA.,greene@reo.med.upenn.edu |
| 英文摘要 | The human FOXP3 molecule is an oligomeric transcriptional factor able to mediate activities that characterize T regulatory cells, a class of lymphocytes central to the regulation of immune responses. The activity of FOXP3 is regulated at the posttranslational level, in part by two histone acetyltransferases (HATs): TIP60 and p300. TIP60 and p300 work cooperatively to regulate FOXP3 activity. Initially, p300 and TIP60 interactions lead to the activation of TIP60 and facilitate acetylation of K327 of TIP60, which functions as a molecular switch to allow TIP60 to change binding partners. Subsequently, p300 is released from this complex, and TIP60 interacts with and acetylates FOXP3. Maximal induction of FOXP3 activities is observed when both p300 and TIP60 are able to undergo cooperative interactions. Conditional knockout of TIP60 in Treg cells significantly decreases the Treg population in the peripheral immune organs, leading to a scurfy-like fatal autoimmune disease. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | ACETYLTRANSFERASE ACTIVITY ; HISTONE ACETYLTRANSFERASE ; T-CELLS ; ACETYLATION ; TRANSCRIPTION ; AUTOACETYLATION ; DEACETYLASES ; INHIBITION ; APOPTOSIS ; PROMOTES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000338324200015 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/187]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xiao, Y,Nagai, Y,Deng, GP,et al. Dynamic Interactions between TIP60 and p300 Regulate FOXP3 Function through a Structural Switch Defined by a Single Lysine on TIP60[J]. CELL REPORTS,2014,7(5):1471-1480. |
| APA | Xiao, Y.,Nagai, Y.,Deng, GP.,Ohtani, T.,Zhu, ZQ.,...&Greene, MI.(2014).Dynamic Interactions between TIP60 and p300 Regulate FOXP3 Function through a Structural Switch Defined by a Single Lysine on TIP60.CELL REPORTS,7(5),1471-1480. |
| MLA | Xiao, Y,et al."Dynamic Interactions between TIP60 and p300 Regulate FOXP3 Function through a Structural Switch Defined by a Single Lysine on TIP60".CELL REPORTS 7.5(2014):1471-1480. |
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