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Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression
文献类型：期刊论文
| 作者 | Xu, CX; Fillmore, CM; Koyama, S; Wu, HB; Zhao, YQ; Chen, Z; Herter-Sprie, GS; Akbay, EA; Tchaicha, JH; Altabef, A |
| 刊名 | CANCER CELL
 |
| 出版日期 | 2014 |
| 卷号 | 25期号:5页码:590-604 |
| 通讯作者 | Hammerman, PS (reprint author), Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA.,phammerman@partners.org ; carla.kim@childrens.harvard.edu ; kwong1@partners.org |
| 英文摘要 | Lung squamous cell carcinoma (SCC) is a deadly disease for which current treatments are inadequate. We demonstrate that biallelic inactivation of Lkb1 and Pten in the mouse lung leads to SCC that recapitulates the histology, gene expression, and microenvironment found in human disease. Lkb1; Pten null (LP) tumors expressed the squamous markers KRT5, p63 and SOX2, and transcriptionally resembled the basal subtype of human SCC. In contrast to mouse adenocarcinomas, the LP tumors contained immune populations enriched for tumor-associated neutrophils. SCA1(+) NGFR(+) fractions were enriched for tumor-propagating cells (TPCs) that could serially transplant the disease in orthotopic assays. TPCs in the LP model and NGFR(+) cells in human SCCs highly expressed Pd-ligand-1 (PD-L1), suggesting a mechanism of immune escape for TPCs. |
| 学科主题 | Oncology; Cell Biology |
| 类目[WOS] | Oncology ; Cell Biology |
| 关键词[WOS] | STEM-CELLS ; SUPPRESSOR-CELLS ; CANCER ; DIFFERENTIATION ; ADENOCARCINOMA ; IDENTIFICATION ; INFLAMMATION ; PROGRESSION ; MECHANISMS ; INFECTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000336025700008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/188]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xu, CX,Fillmore, CM,Koyama, S,et al. Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression[J]. CANCER CELL,2014,25(5):590-604. |
| APA | Xu, CX.,Fillmore, CM.,Koyama, S.,Wu, HB.,Zhao, YQ.,...&Wong, KK.(2014).Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression.CANCER CELL,25(5),590-604. |
| MLA | Xu, CX,et al."Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression".CANCER CELL 25.5(2014):590-604. |
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