Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer
文献类型：期刊论文
| 作者 | Mu, JS; Xu, HN; Yang, Y; Huang, WD; Xiao, J; Li, ML; Tan, ZJ; Ding, QC; Zhang, L; Lu, JH |
| 刊名 | ONCOLOGY REPORTS
 |
| 出版日期 | 2014 |
| 卷号 | 31期号:5页码:2107-2114 |
| 关键词 | thioridazine antipsychotic drug gastric cancer apoptosis caspase mitochondria in vivo |
| 通讯作者 | Liu, YB (reprint author), Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Gen Surg, 1665 Kong Jiang Rd, Shanghai 200092, Peoples R China.,xuhaineng123@163.com ; liuybphd@126.com |
| 英文摘要 | Thioridazine, an antipsychotic drug, has been reported to induce apoptosis in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs). However, whether it elicits anticancer effects in gastric cancer has never been reported. In the present study, we examined the ability of thioridazine to induce cell death in the gastric cancer cell lines NCI-N87 and AGS, and detected its in vivo tumor inhibition capacity. Thioridazine elicited cytotoxic effects on NCI-N87 and AGS cells in a dose-dependent manner, and inhibited the colony formation abilitiy of the NCI-N87 and AGS cells. Thioridazine treatment induced nuclear fragmentation, increased the proportion of sub-G1 phase cells, and elevated the percentage of Annexin V-positive cells, suggesting the occurrence of apoptosis. Moreover, thioridazine induced gastric cancer cell apoptosis in a caspase-dependent manner, as shown by a decrease in the precursors of casapse-9, caspase-8 and caspase-3, and by the ability of the caspase inhibitor Z-VAD-FMK to reverse the cytotoxic effect of thioridazine. JC-1 staining further revealed that thioridazine induced gastric cancer cell apoptosis via the mitochondrial pathway. In addition, thioridazine pretreatment inhibited the growth of NCI-N87 cell-derived tumors. The present study demonstrated that the antipsychotic drug thioridazine possesses anti-gastric cancer ability through in vitro and in vivo experiments, suggesting thioridazine as a potential drug in gastric cancer therapy. |
| 学科主题 | Oncology |
| 类目[WOS] | Oncology |
| 关键词[WOS] | CELL LUNG-CANCER ; MULTIDRUG-RESISTANCE ; INDUCE APOPTOSIS ; P-GLYCOPROTEIN ; STEM-CELLS ; PATHWAY ; LINE ; PHENOTHIAZINES ; IDENTIFICATION ; PROLIFERATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337947200019 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/189]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Mu, JS,Xu, HN,Yang, Y,et al. Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer[J]. ONCOLOGY REPORTS,2014,31(5):2107-2114. |
| APA | Mu, JS.,Xu, HN.,Yang, Y.,Huang, WD.,Xiao, J.,...&Liu, YB.(2014).Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer.ONCOLOGY REPORTS,31(5),2107-2114. |
| MLA | Mu, JS,et al."Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer".ONCOLOGY REPORTS 31.5(2014):2107-2114. |
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