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Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus
文献类型：期刊论文
| 作者 | Xiang, JF; Yin, QF; Chen, T; Zhang, Y; Zhang, XO; Wu, Z; Zhang, SF; Wang, HB; Ge, JH; Lu, XH |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2014 |
| 卷号 | 24期号:5页码:513-531 |
| 关键词 | CCAT1-L lncRNA super-enhancer chromatin looping MYC CTCF |
| 通讯作者 | Chen, LL (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,linglingchen@sibcb.ac.cn |
| 英文摘要 | The human 8q24 gene desert contains multiple enhancers that form tissue-specific long-range chromatin loops with the MYC oncogene, but how chromatin looping at the MYC locus is regulated remains poorly understood. Here we demonstrate that a long noncoding RNA (lncRNA), CCAT1-L, is transcribed specifically in human colorectal cancers from a locus 515 kb upstream of MYC. This lncRNA plays a role in MYC transcriptional regulation and promotes long-range chromatin looping. Importantly, the CCAT1-L locus is located within a strong super-enhancer and is spatially close to MYC. Knockdown of CCAT1-L reduced long-range interactions between the MYC promoter and its enhancers. In addition, CCAT1-L interacts with CTCF and modulates chromatin conformation at these loop regions. These results reveal an important role of a previously unannotated lncRNA in gene regulation at the MYC locus. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | NONCODING RNA ; COLON-CANCER ; TRANSCRIPTION FACTORS ; SUPER-ENHANCERS ; LINEAGE COMMITMENT ; GENE-EXPRESSION ; CELL IDENTITY ; SNP RS6983267 ; HUMAN GENOME ; CTCF |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000335914700002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/190]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xiang, JF,Yin, QF,Chen, T,et al. Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus[J]. CELL RESEARCH,2014,24(5):513-531. |
| APA | Xiang, JF.,Yin, QF.,Chen, T.,Zhang, Y.,Zhang, XO.,...&Chen, LL.(2014).Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus.CELL RESEARCH,24(5),513-531. |
| MLA | Xiang, JF,et al."Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus".CELL RESEARCH 24.5(2014):513-531. |
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