The Mediator complex: a master coordinator of transcription and cell lineage development
文献类型：期刊论文
| 作者 | Yin, JW; Wang, G |
| 刊名 | DEVELOPMENT
 |
| 出版日期 | 2014 |
| 卷号 | 141期号:5页码:977-987 |
| 关键词 | Mediator complex Transcription Cell fate Lineage development Disease |
| 通讯作者 | Wang, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,gwang@sibcb.ac.cn |
| 英文摘要 | Mediator is a multiprotein complex that is required for gene transcription by RNA polymerase II. Multiple subunits of the complex show specificity in relaying information from signals and transcription factors to the RNA polymerase II machinery, thus enabling control of the expression of specific genes. Recent studies have also provided novel mechanistic insights into the roles of Mediator in epigenetic regulation, transcriptional elongation, termination, mRNA processing, noncoding RNA activation and super enhancer formation. Based on these specific roles in gene regulation, Mediator has emerged as a master coordinator of development and cell lineage determination. Here, we describe the most recent advances in understanding the mechanisms of Mediator function, with an emphasis on its role during development and disease. |
| 学科主题 | Developmental Biology |
| 类目[WOS] | Developmental Biology |
| 关键词[WOS] | RNA-POLYMERASE-II ; PROLIFERATOR-ACTIVATED RECEPTOR ; THYROID-HORMONE RECEPTOR ; SMOOTH-MUSCLE-CELL ; GENE-EXPRESSION ; BINDING PROTEIN ; COACTIVATOR COMPLEX ; NUCLEAR RECEPTORS ; MAMMALIAN MEDIATOR ; DIRECT CONVERSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000331880900001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/193]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yin, JW,Wang, G. The Mediator complex: a master coordinator of transcription and cell lineage development[J]. DEVELOPMENT,2014,141(5):977-987. |
| APA | Yin, JW,&Wang, G.(2014).The Mediator complex: a master coordinator of transcription and cell lineage development.DEVELOPMENT,141(5),977-987. |
| MLA | Yin, JW,et al."The Mediator complex: a master coordinator of transcription and cell lineage development".DEVELOPMENT 141.5(2014):977-987. |
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