Thyroid hormone regulates muscle fiber type conversion via miR-133a1
文献类型：期刊论文
| 作者 | Zhang, D; Wang, XY; Li, YY; Zhao, L; Lu, MH; Yao, X; Xia, HF; Wang, YC; Liu, MF; Jiang, JJ |
| 刊名 | JOURNAL OF CELL BIOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 207期号:6页码:753-766 |
| 通讯作者 | Ying, H (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai 200031, Peoples R China.,yinghao@sibs.ac.cn |
| 英文摘要 | It is known that thyroid hormone (TH) is a major determinant of muscle fiber composition, but the molecular mechanism by which it does so remains unclear. Here, we demonstrated that miR-133a1 is a direct target gene of TH in muscle. Intriguingly, miR-133a, which is enriched in fast-twitch muscle, regulates slow-to-fast muscle fiber type conversion by targeting TEA domain family member 1 (TEAD1), a key regulator of slow muscle gene expression. Inhibition of miR-133a in vivo abrogated TH action on muscle fiber type conversion. Moreover, TEAD1 overexpression antagonized the effect of miR-133a as well as TH on muscle fiber type switch. Additionally, we demonstrate that TH negatively regulates the transcription of myosin heavy chain I indirectly via miR-133a/TEAD1. Collectively, we propose that TH inhibits the slow muscle phenotype through a novel epigenetic mechanism involving repression of TEAD1 expression via targeting by miR-133a1. This identification of a TH-regulated microRNA therefore sheds new light on how TH achieves its diverse biological activities. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | SKELETAL-MUSCLE ; CONTRACTILE PHENOTYPE ; NEURAL REGULATION ; GENE-EXPRESSION ; RECEPTOR-BETA ; MICE ; TRANSITIONS ; ENHANCER ; FAMILY ; DIFFERENTIATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000346821500008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/197]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, D,Wang, XY,Li, YY,et al. Thyroid hormone regulates muscle fiber type conversion via miR-133a1[J]. JOURNAL OF CELL BIOLOGY,2014,207(6):753-766. |
| APA | Zhang, D.,Wang, XY.,Li, YY.,Zhao, L.,Lu, MH.,...&Ying, H.(2014).Thyroid hormone regulates muscle fiber type conversion via miR-133a1.JOURNAL OF CELL BIOLOGY,207(6),753-766. |
| MLA | Zhang, D,et al."Thyroid hormone regulates muscle fiber type conversion via miR-133a1".JOURNAL OF CELL BIOLOGY 207.6(2014):753-766. |
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