Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation
文献类型：期刊论文
| 作者 | Cheng, T; Liu, QB; Zhang, R; Zhang, Y; Chen, JF; Yu, RH; Ge, GX |
| 刊名 | JOURNAL OF MOLECULAR CELL BIOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 6期号:6页码:506-515 |
| 关键词 | lysyl oxidase lung fibrosis inflammation bleomycin animal models extracellular matrix |
| 通讯作者 | Ge, GX (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,gxge@sibcb.ac.cn |
| 英文摘要 | Enzymes involved in collagen biosynthesis, including lysyl oxidase (LOX), have been proposed as potential therapeutic targets for idiopathic pulmonary fibrosis. LOX expression is significantly upregulated in bleomycin (BLM)-induced lung fibrosis, and knockdown of LOX expression or inhibition of LOX activity alleviates the lung fibrosis. Unexpectedly, treatment of the mice with LOX inhibitor at the inflammatory stage, but not the fibrogenic stage, efficiently reduces collagen deposition and normalizes lung architecture. Inhibition of LOXimpairs inflammatory cell infiltration, TGF-bsignaling, andmyofibroblast accumulation. Furthermore, ectopic expression of LOXsensitizes the fibrosis-resistant Balb/c mice to BLM-induced inflammation and lung fibrosis. These results suggest that LOX is indispensable for the progression of BLM-induced experimental lung fibrosis by aggravating the inflammatory response and subsequent fibrosis process after lung injury. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | IDIOPATHIC PULMONARY-FIBROSIS ; CANCER PROGRESSION ; COLLAGEN ; METASTASIS ; DISEASE ; MACROPHAGE ; ROLES ; CELL ; CARCINOMAS ; EXPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000348600100007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/200]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Cheng, T,Liu, QB,Zhang, R,et al. Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2014,6(6):506-515. |
| APA | Cheng, T.,Liu, QB.,Zhang, R.,Zhang, Y.,Chen, JF.,...&Ge, GX.(2014).Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation.JOURNAL OF MOLECULAR CELL BIOLOGY,6(6),506-515. |
| MLA | Cheng, T,et al."Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation".JOURNAL OF MOLECULAR CELL BIOLOGY 6.6(2014):506-515. |
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