Whole-genome sequencing of six dog breeds from continuous altitudes reveals adaptation to high-altitude hypoxia
文献类型：期刊论文
| 作者 | Gou, X; Wang, Z; Li, N; Qiu, F; Xu, Z; Yan, DW; Yang, SL; Jia, J; Kong, XY; Wei, ZH |
| 刊名 | GENOME RESEARCH
 |
| 出版日期 | 2014 |
| 卷号 | 24期号:8页码:1308-1315 |
| 通讯作者 | Mao, HM (reprint author), Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China.,maohm@vip.sina.com ; zhanghao827@163.com ; gwding@sibs.ac.cn ; yxli@sibs.ac.cn |
| 英文摘要 | The hypoxic environment imposes severe selective pressure on species living at high altitude. To understand the genetic bases of adaptation to high altitude in dogs, we performed whole-genome sequencing of 60 dogs including five breeds living at continuous altitudes along the Tibetan Plateau from 800 to 5100 m as well as one European breed. More than 150x sequencing coverage for each breed provides us with a comprehensive assessment of the genetic polymorphisms of the dogs, including Tibetan Mastiffs. Comparison of the breeds from different altitudes reveals strong signals of population differentiation at the locus of hypoxia-related genes including endothelial Per-Arnt-Sim (PAS) domain protein 1 (EPAS1) and beta hemoglobin cluster. Notably, four novel nonsynonymous mutations specific to high-altitude dogs are identified at EPAS1, one of which occurred at a quite conserved site in the PAS domain. The association testing between EPAS1 genotypes and blood-related phenotypes on additional high-altitude dogs reveals that the homozygous mutation is associated with decreased blood flow resistance, which may help to improve hemorheologic fitness. Interestingly, EPAS1 was also identified as a selective target in Tibetan highlanders, though no amino acid changes were found. Thus, our results not only indicate parallel evolution of humans and dogs in adaptation to high-altitude hypoxia, but also provide a new opportunity to study the role of EPAS1 in the adaptive processes. |
| 学科主题 | Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 关键词[WOS] | HEADED GOOSE HEMOGLOBIN ; HIGH OXYGEN-AFFINITY ; POSITIVE SELECTION ; NATURAL-SELECTION ; CRYSTAL-STRUCTURE ; HIF2A GENE ; TIBETAN ; POPULATIONS ; MECHANISM ; ERYTHROCYTOSIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000339860200006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/214]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Gou, X,Wang, Z,Li, N,et al. Whole-genome sequencing of six dog breeds from continuous altitudes reveals adaptation to high-altitude hypoxia[J]. GENOME RESEARCH,2014,24(8):1308-1315. |
| APA | Gou, X.,Wang, Z.,Li, N.,Qiu, F.,Xu, Z.,...&Li, YX.(2014).Whole-genome sequencing of six dog breeds from continuous altitudes reveals adaptation to high-altitude hypoxia.GENOME RESEARCH,24(8),1308-1315. |
| MLA | Gou, X,et al."Whole-genome sequencing of six dog breeds from continuous altitudes reveals adaptation to high-altitude hypoxia".GENOME RESEARCH 24.8(2014):1308-1315. |
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