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Perivascular Adipose Tissue in Vascular Function and Disease A Review of Current Research and Animal Models
文献类型：期刊论文
| 作者 | Brown, NK; Zhou, Z; Zhang, JF; Zeng, R; Wu, JR; Eitzman, DT; Chen, YE; Chang, L |
| 刊名 | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 34期号:8页码:1621-1630 |
| 关键词 | adipose tissue atherosclerosis hypertension |
| 通讯作者 | Chang, L (reprint author), Univ Michigan, Med Ctr, Dept Internal Med, Cardiovasc Ctr, 2800 Plymouth Rd, Ann Arbor, MI 48109 USA.,echenum@umich.edu |
| 英文摘要 | Perivascular adipose tissue (PVAT), long assumed to be nothing more than vessel-supporting connective tissue, is now understood to be an important, active component of the vasculature, with integral roles in vascular health and disease. PVAT is an adipose tissue with similarities to both brown and white adipose tissue, although recent evidence suggests that PVAT develops from its own precursors. Like other adipose tissue depots, PVAT secretes numerous biologically active substances that can act in both autocrine and paracrine fashion. PVAT has also proven to be involved in vascular inflammation. Although PVAT can support inflammation during atherosclerosis via macrophage accumulation, emerging evidence suggests that PVAT also has antiatherosclerotic properties related to its abilities to induce nonshivering thermogenesis and metabolize fatty acids. We here discuss the accumulated knowledge of PVAT biology and related research on models of hypertension and atherosclerosis. |
| 学科主题 | Hematology ; Cardiovascular System & Cardiology |
| 类目[WOS] | Hematology ; Peripheral Vascular Disease |
| 关键词[WOS] | CORONARY ENDOTHELIAL DYSFUNCTION ; NITRIC-OXIDE SYNTHASE ; E-DEFICIENT MICE ; SMOOTH-MUSCLE ; BROWN-FAT ; OXIDATIVE STRESS ; WHITE FAT ; METABOLIC SYNDROME ; BEIGE ADIPOCYTES ; BLOOD-PRESSURE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000339274200006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/215]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Brown, NK,Zhou, Z,Zhang, JF,et al. Perivascular Adipose Tissue in Vascular Function and Disease A Review of Current Research and Animal Models[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,2014,34(8):1621-1630. |
| APA | Brown, NK.,Zhou, Z.,Zhang, JF.,Zeng, R.,Wu, JR.,...&Chang, L.(2014).Perivascular Adipose Tissue in Vascular Function and Disease A Review of Current Research and Animal Models.ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,34(8),1621-1630. |
| MLA | Brown, NK,et al."Perivascular Adipose Tissue in Vascular Function and Disease A Review of Current Research and Animal Models".ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 34.8(2014):1621-1630. |
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