Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth
文献类型：期刊论文
| 作者 | Yin, Y; Cai, X; Chen, X; Liang, HW; Zhang, YJ; Li, J; Wang, ZY; Chen, XL; Zhang, W; Yokoyama, S |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2014 |
| 卷号 | 24期号:10页码:1164-1180 |
| 关键词 | secreted microRNA regulatory T cell PTEN microvesicle immune evasion tumor |
| 通讯作者 | Yin, Y (reprint author), Nanjing Univ, JERC MBB, State Key Lab Pharmaceut Biotechnol, Sch Life Sci, 22 Hankou Rd, Nanjing 210093, Jiangsu, Peoples R China.,cyzhang@nju.edu.cn ; jfzhang@nju.edu.cn ; kzen@nju.edu.cn |
| 英文摘要 | An increased population of CD4(+)CD25(high)Foxp3(+) regulatory T cells (Tregs) in the tumor-associated microenvironment plays an important role in cancer immune evasion. However, the underlying mechanism remains unclear. Here we observed an increased secretion of miR-214 in various types of human cancers and mouse tumor models. Tumor-secreted miR-214 was sufficiently delivered into recipient T cells by microvesicles (MVs). In targeted mouse peripheral CD4(+) T cells, tumor-derived miR-214 efficiently downregulated phosphatase and tensin homolog (PTEN) and promoted Treg expansion. The miR-214-induced Tregs secreted higher levels of IL-10 and promoted tumor growth in nude mice. Furthermore, in vivo studies indicated that Treg expansion mediated by cancer cell-secreted miR-214 resulted in enhanced immune suppression and tumor implantation/growth in mice. The MV delivery of anti-miR-214 antisense oligonucleotides (ASOs) into mice implanted with tumors blocked Treg expansion and tumor growth. Our study reveals a novel mechanism through which cancer cell actively manipulates immune response via promoting Treg expansion. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | LUNG-CANCER ; EXPRESSION ; TOLERANCE ; MICE ; PROGRESSION ; MICRORNAS ; DEPLETION ; MELANOMA ; MICROVESICLES ; PROLIFERATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000344993300007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/232]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yin, Y,Cai, X,Chen, X,et al. Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth[J]. CELL RESEARCH,2014,24(10):1164-1180. |
| APA | Yin, Y.,Cai, X.,Chen, X.,Liang, HW.,Zhang, YJ.,...&Zhang, CY.(2014).Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth.CELL RESEARCH,24(10),1164-1180. |
| MLA | Yin, Y,et al."Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth".CELL RESEARCH 24.10(2014):1164-1180. |
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