Next-Generation Models of Human Cardiogenesis via Genome Editing
文献类型：期刊论文
| 作者 | Lian, XJ; Xu, JJ; Li, JS; Chien, KR |
| 刊名 | COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
 |
| 出版日期 | 2014 |
| 卷号 | 4期号:12页码:a013920-a013920 |
| 通讯作者 | Chien, KR (reprint author), Karolinska Inst, Dept Cell & Mol Biol, S-17177 Solna, Sweden.,kenneth.chien@ki.se |
| 英文摘要 | Cardiogenesis is one of the earliest and most important steps during human development and is orchestrated by discrete families of heart progenitors, which build distinct regions of the fetal heart. For the past decade, a lineage map for the distinct subsets of progenitors that generate the embryonic mammalian heart has begun to lay a foundation for the development of new strategies for rebuilding the adult heart after injury, an unmet clinical need for the vast majority of patients with end-stage heart failure who are not heart transplant recipients. The studies also have implications for the root causes of congenital heart disease, which affects 1 in 50 live births, the most prevalent malformations in children. Although much of this insight has been generated in murine models, it is becoming increasingly clear that there can be important divergence with principles and pathways for human cardiogenesis, as well as for regenerative pathways. The development of human stem cell models, coupled with recent advances in genome editing with RNA-guided endonucleases, offers a new approach for the primary study of human cardiogenesis. In addition, application of the technology to the in vivo setting in large animal models, including nonhuman primates, has opened the door to genome-edited large animal models of adult and congenital heart disease, as well as a detailed mechanistic dissection of the more diverse and complex set of progenitor families and pathways, which guide human cardiogenesis. Implications of this new technology for a new generation of human-based, genetically tractable systems are discussed, along with potential therapeutic applications. |
| 学科主题 | Research & Experimental Medicine |
| 类目[WOS] | Medicine, Research & Experimental |
| 关键词[WOS] | EMBRYONIC STEM-CELLS ; CRISPR-CAS SYSTEMS ; ENDOTHELIAL-CELLS ; CARDIAC DIFFERENTIATION ; PROGENITOR CELLS ; CARDIOMYOCYTE DIFFERENTIATION ; CONDITIONAL ALLELES ; HEART PROGENITORS ; GENETIC SCREENS ; MOUSE EMBRYOS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000346523200001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/245]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Lian, XJ,Xu, JJ,Li, JS,et al. Next-Generation Models of Human Cardiogenesis via Genome Editing[J]. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE,2014,4(12):a013920-a013920. |
| APA | Lian, XJ,Xu, JJ,Li, JS,&Chien, KR.(2014).Next-Generation Models of Human Cardiogenesis via Genome Editing.COLD SPRING HARBOR PERSPECTIVES IN MEDICINE,4(12),a013920-a013920. |
| MLA | Lian, XJ,et al."Next-Generation Models of Human Cardiogenesis via Genome Editing".COLD SPRING HARBOR PERSPECTIVES IN MEDICINE 4.12(2014):a013920-a013920. |
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