A new kind of cell suicide: mechanisms and functions of programmed necrosis
文献类型：期刊论文
| 作者 | Sun, LM; Wang, XD |
| 刊名 | TRENDS IN BIOCHEMICAL SCIENCES
 |
| 出版日期 | 2014 |
| 卷号 | 39期号:12页码:587-593 |
| 关键词 | programmed necrosis pseudokinase mixed lineage kinase domain-like protein (MLKL) necroptosis necrosis inhibitors necrosis biomarker |
| 通讯作者 | Sun, LM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,liming.sun@sibcb.ac.cn |
| 英文摘要 | Classically, there are two major forms of cell death: necrosis, an unregulated digestion of cellular components; and apoptosis, a programmed mechanism that is promoted by caspases. However, another form of cell death has recently been identified that is inhibited by caspases, and yet occurs through a regulated mechanism, termed programmed necrosis or necroptosis. The biochemical basis of this program has begun to emerge, with the discovery of the receptor-interacting kinase RIP3 and its substrate, the pseudokinase mixed lineage kinase domain-like protein (MLKL), as core components. Furthermore, animal models have revealed significant functions for RIP3/MLKL-mediated necrotic cell death in immune responses against microbial infection and in the etiology of diseases involving tissue damage. This review discusses recent advances in our understanding of the mechanistic details and physiological functions of programmed necrosis. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | MIXED LINEAGE KINASE ; DOMAIN-LIKE PROTEIN ; NF-KAPPA-B ; ALPHA-DEPENDENT APOPTOSIS ; TNF-ALPHA ; MEDIATES NECROPTOSIS ; SIGNALING COMPLEX ; DEATH PATHWAYS ; RIP1 KINASE ; RECEPTOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000346233300004 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/248]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Sun, LM,Wang, XD. A new kind of cell suicide: mechanisms and functions of programmed necrosis[J]. TRENDS IN BIOCHEMICAL SCIENCES,2014,39(12):587-593. |
| APA | Sun, LM,&Wang, XD.(2014).A new kind of cell suicide: mechanisms and functions of programmed necrosis.TRENDS IN BIOCHEMICAL SCIENCES,39(12),587-593. |
| MLA | Sun, LM,et al."A new kind of cell suicide: mechanisms and functions of programmed necrosis".TRENDS IN BIOCHEMICAL SCIENCES 39.12(2014):587-593. |
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