Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis
文献类型：期刊论文
| 作者 | Li, HS; Yue, R; Wei, B; Gao, G; Du, JL; Pei, G |
| 刊名 | EMBO JOURNAL
 |
| 出版日期 | 2014 |
| 卷号 | 33期号:12页码:1383-1396 |
| 关键词 | embryonic stem cell hemangioblast hematopoiesis LPA zebrafish |
| 通讯作者 | Pei, G (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, State Key Lab Cell Biol,Inst Biochem & Cell Biol, Shanghai, Peoples R China.,gpei@sibs.ac.cn |
| 英文摘要 | Primitive hematopoiesis occurs in the yolk sac blood islands during vertebrate embryogenesis, where abundant phosphatidylcholines (PC) are available as important nutrients for the developing embryo. However, whether these phospholipids also generate developmental cues to promote hematopoiesis is largely unknown. Here, we show that lysophosphatidic acid (LPA), a signaling molecule derived from PC, regulated hemangioblast formation and primitive hematopoiesis. Pharmacological and genetic blockage of LPA receptor 1 (LPAR1) or autotoxin (ATX), a secretory lysophospholipase that catalyzes LPA production, inhibited hematopoietic differentiation of mouse embryonic stem cells and impaired the formation of hemangioblasts. Mechanistic experiments revealed that the regulatory effect of ATX-LPA signaling was mediated by PI3K/Akt-Smad pathway. Furthermore, during in vivo embryogenesis in zebrafish, LPA functioned as a developmental cue for hemangioblast formation and primitive hematopoiesis. Taken together, we identified LPA as an important nutrient-derived developmental cue for primitive hematopoiesis as well as a novel mechanism of hemangioblast regulation. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | EMBRYONIC STEM-CELLS ; BONE MORPHOGENETIC PROTEIN-4 ; ENDOTHELIAL-CELLS ; LYSOPHOSPHOLIPASE-D ; HEMANGIOBLAST DEVELOPMENT ; HAEMOGENIC ENDOTHELIUM ; VASCULAR MATURATION ; COUPLED RECEPTOR ; COMMON PRECURSOR ; PRIMITIVE STREAK |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000338024100011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/253]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, HS,Yue, R,Wei, B,et al. Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis[J]. EMBO JOURNAL,2014,33(12):1383-1396. |
| APA | Li, HS,Yue, R,Wei, B,Gao, G,Du, JL,&Pei, G.(2014).Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis.EMBO JOURNAL,33(12),1383-1396. |
| MLA | Li, HS,et al."Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis".EMBO JOURNAL 33.12(2014):1383-1396. |
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