FGFR1/3 Tyrosine Kinase Fusions Define a Unique Molecular Subtype of Non-Small Cell Lung Cancer
文献类型：期刊论文
| 作者 | Wang, R; Wang, L; Li, Y; Hu, HC; Shen, L; Shen, XX; Pan, YJ; Ye, T; Zhang, Y; Luo, XY |
| 刊名 | CLINICAL CANCER RESEARCH
 |
| 出版日期 | 2014 |
| 卷号 | 20期号:15页码:4107-4114 |
| 通讯作者 | Sun, YH (reprint author), Fudan Univ, Shanghai Canc Ctr, Dept Thorac Surg, 270 DongAn Rd, Shanghai 200032, Peoples R China.,hbji@sibcb.ac.cn ; sun_yihua76@hotmail.com ; hqchen1@yahoo.com |
| 英文摘要 | Purpose: The fibroblast growth factor receptor (FGFR)-3 fusion genes have been recently demonstrated in a subset of non-small cell lung cancer (NSCLC). To aid in identification and treatment of these patients, we examined the frequency, clinicopathologic characteristics, and treatment outcomes of patients who had NSCLC with or without FGFR fusions. Experimental Design: Fourteen known FGFR fusion variants, including FGFR1, FGFR2, and FGFR3, were detected by RT-PCR and verified by direct sequencing in 1,328 patients with NSCLC. All patients were also analyzed for mutations in EGFR, KRAS, HER2, BRAF, ALK, RET, and ROS1. Clinical characteristics, including age, sex, smoking status, stage, subtypes of lung adenocarcinoma, relapse-free survival, and overall survival, were collected. Results: Of 1,328 tumors screened, two (0.2%) were BA G4-FGFR1 fusion and 15 (1.1%) were FGFR3-TACC3 fusion. Six of 1,016 patients with lung adenocarcinoma were FGFR3-TACC3 fusions and 11 of 312 lung squamous cell carcinoma harbored BAG4-FGFR1 or FGFR3-TACC3 fusions. Compared with the FGFR fusion-negative group, patients with FGFR fusions were more likely to be smokers (94.1%, 16 of 17 patients, P < 0.001), significantly associated with larger tumor (>3 cm; 88.2%, 15 of 17 patients, P < 0.001) and with a tendency to be more poorly differentiated (53.9%, nine of 17 patients, P = 0.095). Conclusions: FGFR fusions define a molecular subset of NSCLC with distinct clinical characteristics. FGFR is a druggable target and patients with FGFR fusions may benefit from FGFR-targeted therapy, which needs further clinical investigation. (C) 2014 AACR. |
| 学科主题 | Oncology |
| 类目[WOS] | Oncology |
| 关键词[WOS] | RET FUSIONS ; ALK ; MUTATIONS ; ADENOCARCINOMAS ; REARRANGEMENTS ; GLIOBLASTOMA ; CARCINOMA ; ROS1 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000340179500021 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/256]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, R,Wang, L,Li, Y,et al. FGFR1/3 Tyrosine Kinase Fusions Define a Unique Molecular Subtype of Non-Small Cell Lung Cancer[J]. CLINICAL CANCER RESEARCH,2014,20(15):4107-4114. |
| APA | Wang, R.,Wang, L.,Li, Y.,Hu, HC.,Shen, L.,...&Chen, HQ.(2014).FGFR1/3 Tyrosine Kinase Fusions Define a Unique Molecular Subtype of Non-Small Cell Lung Cancer.CLINICAL CANCER RESEARCH,20(15),4107-4114. |
| MLA | Wang, R,et al."FGFR1/3 Tyrosine Kinase Fusions Define a Unique Molecular Subtype of Non-Small Cell Lung Cancer".CLINICAL CANCER RESEARCH 20.15(2014):4107-4114. |
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