Tet-mediated formation of 5-hydroxymethylcytosine in RNA
文献类型：期刊论文
| 作者 | Fu, LJ; Guerrero, CR; Zhong, N; Navarro, D; Niedernhofer, LJ; Pfeifer, GP; Xu, GL; Wang, YS |
| 刊名 | ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2014 |
| 卷号 | 248期号:1页码:42006 |
| 通讯作者 | ,lfu002@ucr.edu |
| 英文摘要 | Oxidation of 5-methylcytosine in DNA by ten-eleven translocation (Tet) family of enzymes has been demonstrated to play a significant role in epigenetic regulation in mammals. We found that Tet enzymes also possess the activity of catalyzing the formation of 5-hydroxymethylcytidine (5-hmrC) in RNA in vitro. In addition, the catalytic domains of all three Tet enzymes as well as full-length Tet3 could induce the formation of 5-hmrC in human cells. Moreover, 5-hmrC was present at appreciable levels (similar to 1 per 5000 5-methylcytidine) in RNA of mammalian cells and tissues. Our results suggest the involvement of this oxidation in RNA biology. |
| 学科主题 | Chemistry |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 关键词[WOS] | NONCODING RNA ; MAMMALIAN DNA ; 5-METHYLCYTOSINE ; METHYLATION ; 5-CARBOXYLCYTOSINE ; 5-FORMYLCYTOSINE ; DEMETHYLATION ; SUBSTRATE ; PROTEINS ; WIDESPREAD |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000349167406261 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/269]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Fu, LJ,Guerrero, CR,Zhong, N,et al. Tet-mediated formation of 5-hydroxymethylcytosine in RNA[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,2014,248(1):42006. |
| APA | Fu, LJ.,Guerrero, CR.,Zhong, N.,Navarro, D.,Niedernhofer, LJ.,...&Wang, YS.(2014).Tet-mediated formation of 5-hydroxymethylcytosine in RNA.ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,248(1),42006. |
| MLA | Fu, LJ,et al."Tet-mediated formation of 5-hydroxymethylcytosine in RNA".ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 248.1(2014):42006. |
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