Drosophila Casein Kinase 2 (CK2) Promotes Warts Protein to Suppress Yorkie Protein Activity for Growth Control
文献类型：期刊论文
| 作者 | Hu, LX; Huang, HL; Li, JH; Yin, MX; Lu, Y; Wu, WQ; Zeng, R; Jiang, J; Zhao, Y; Zhang, L |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2014 |
| 卷号 | 289期号:48页码:33598-33607 |
| 通讯作者 | Zhang, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Yue Yang Rd, Shanghai 200031, Peoples R China.,rayzhang@sibcb.ac.cn |
| 英文摘要 | Drosophila Hippo signaling regulates Wts activity to phosphorylate and inhibit Yki in order to control tissue growth. CK2 is widely expressed and involved in a variety of signaling pathways. In this study we report that Drosophila CK2 promotes Wts activity to phosphorylate and inhibit Yki activity, which is independent of Hpo-induced Wts promotion. In vivo, CK2 overexpression suppresses hpo mutant-induced expanded (Ex) up-regulation and overgrowth phenotype, whereas it cannot affect wts mutant. Consistent with this, knockdown of CK2 up-regulates Hpo pathway target expression. We also found that Drosophila CK2 is essential for tissue growth as a cell death inhibitor as knockdown of CK2 in the developing disc induces severe growth defects as well as caspase3 signals. Taken together, our results uncover a dual role of CK2; although its major role is promoting cell survive, it may potentially be a growth inhibitor as well. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | HIPPO SIGNALING PATHWAY ; ORGAN SIZE CONTROL ; CELL-CYCLE EXIT ; TUMOR-SUPPRESSOR ; IN-VIVO ; PROLIFERATION ARREST ; TEAD/TEF FAMILY ; BANTAM MICRORNA ; BETA-SUBUNIT ; APOPTOSIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000345636600045 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/272]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Hu, LX,Huang, HL,Li, JH,et al. Drosophila Casein Kinase 2 (CK2) Promotes Warts Protein to Suppress Yorkie Protein Activity for Growth Control[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2014,289(48):33598-33607. |
| APA | Hu, LX.,Huang, HL.,Li, JH.,Yin, MX.,Lu, Y.,...&Zhang, L.(2014).Drosophila Casein Kinase 2 (CK2) Promotes Warts Protein to Suppress Yorkie Protein Activity for Growth Control.JOURNAL OF BIOLOGICAL CHEMISTRY,289(48),33598-33607. |
| MLA | Hu, LX,et al."Drosophila Casein Kinase 2 (CK2) Promotes Warts Protein to Suppress Yorkie Protein Activity for Growth Control".JOURNAL OF BIOLOGICAL CHEMISTRY 289.48(2014):33598-33607. |
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