中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Drosophila Casein Kinase 2 (CK2) Promotes Warts Protein to Suppress Yorkie Protein Activity for Growth Control

文献类型:期刊论文

作者Hu, LX; Huang, HL; Li, JH; Yin, MX; Lu, Y; Wu, WQ; Zeng, R; Jiang, J; Zhao, Y; Zhang, L
刊名JOURNAL OF BIOLOGICAL CHEMISTRY
出版日期2014
卷号289期号:48页码:33598-33607
通讯作者Zhang, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Yue Yang Rd, Shanghai 200031, Peoples R China.,rayzhang@sibcb.ac.cn
英文摘要Drosophila Hippo signaling regulates Wts activity to phosphorylate and inhibit Yki in order to control tissue growth. CK2 is widely expressed and involved in a variety of signaling pathways. In this study we report that Drosophila CK2 promotes Wts activity to phosphorylate and inhibit Yki activity, which is independent of Hpo-induced Wts promotion. In vivo, CK2 overexpression suppresses hpo mutant-induced expanded (Ex) up-regulation and overgrowth phenotype, whereas it cannot affect wts mutant. Consistent with this, knockdown of CK2 up-regulates Hpo pathway target expression. We also found that Drosophila CK2 is essential for tissue growth as a cell death inhibitor as knockdown of CK2 in the developing disc induces severe growth defects as well as caspase3 signals. Taken together, our results uncover a dual role of CK2; although its major role is promoting cell survive, it may potentially be a growth inhibitor as well.
学科主题Biochemistry & Molecular Biology
类目[WOS]Biochemistry & Molecular Biology
关键词[WOS]HIPPO SIGNALING PATHWAY ; ORGAN SIZE CONTROL ; CELL-CYCLE EXIT ; TUMOR-SUPPRESSOR ; IN-VIVO ; PROLIFERATION ARREST ; TEAD/TEF FAMILY ; BANTAM MICRORNA ; BETA-SUBUNIT ; APOPTOSIS
收录类别SCI
语种英语
WOS记录号WOS:000345636600045
版本出版稿
源URL[http://202.127.25.143/handle/331003/272]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式
GB/T 7714
Hu, LX,Huang, HL,Li, JH,et al. Drosophila Casein Kinase 2 (CK2) Promotes Warts Protein to Suppress Yorkie Protein Activity for Growth Control[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2014,289(48):33598-33607.
APA Hu, LX.,Huang, HL.,Li, JH.,Yin, MX.,Lu, Y.,...&Zhang, L.(2014).Drosophila Casein Kinase 2 (CK2) Promotes Warts Protein to Suppress Yorkie Protein Activity for Growth Control.JOURNAL OF BIOLOGICAL CHEMISTRY,289(48),33598-33607.
MLA Hu, LX,et al."Drosophila Casein Kinase 2 (CK2) Promotes Warts Protein to Suppress Yorkie Protein Activity for Growth Control".JOURNAL OF BIOLOGICAL CHEMISTRY 289.48(2014):33598-33607.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

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