Functional Analysis of Long Noncoding RNAs in Development and Disease
文献类型：期刊论文
| 作者 | Chen, LL; Zhao, JC |
| 刊名 | SYSTEMS BIOLOGY OF RNA BINDING PROTEINS
 |
| 出版日期 | 2014 |
| 卷号 | 825期号:1页码:129-158 |
| 关键词 | Epigenetics Long noncoding RNA Xist sno-lncRNA Cancer RIP-seq CLIP-seq Chart ChIRP |
| 通讯作者 | Chen, LL (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,linglingchen@sibcb.ac.cn ; czhao@sanfordburnham.org |
| 英文摘要 | Once viewed as part of the "dark matter" of genome, long noncoding RNAs (lncRNAs), which are mRNA-like but lack open reading frames, have emerged as an integral part of the mammalian transcriptome. Recent work demonstrated that lncRNAs play multiple structural and functional roles, and their analysis has become a new frontier in biomedical research. In this chapter, we provide an overview of different lncRNA families, describe methodologies available to study lncRNA-protein and lncRNA-DNA interactions systematically, and use well-studied lncRNAs as examples to illustrate their functional importance during normal development and in disease states. |
| 学科主题 | Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology |
| 类目[WOS] | Biology ; Mathematical & Computational Biology |
| 关键词[WOS] | X-CHROMOSOME INACTIVATION ; GENOME-WIDE IDENTIFICATION ; H3 LYSINE-27 METHYLATION ; PRADER-WILLI-SYNDROME ; EMBRYONIC STEM-CELLS ; XIST RNA ; BINDING PROTEIN ; GENE-EXPRESSION ; A-REPEAT ; METHYLTRANSFERASE ACTIVITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350418400005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/304]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Chen, LL,Zhao, JC. Functional Analysis of Long Noncoding RNAs in Development and Disease[J]. SYSTEMS BIOLOGY OF RNA BINDING PROTEINS,2014,825(1):129-158. |
| APA | Chen, LL,&Zhao, JC.(2014).Functional Analysis of Long Noncoding RNAs in Development and Disease.SYSTEMS BIOLOGY OF RNA BINDING PROTEINS,825(1),129-158. |
| MLA | Chen, LL,et al."Functional Analysis of Long Noncoding RNAs in Development and Disease".SYSTEMS BIOLOGY OF RNA BINDING PROTEINS 825.1(2014):129-158. |
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