Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3 beta
文献类型：期刊论文
| 作者 | Jing, P; Zhang, JY; Ouyang, Q; Wu, J; Zhang, XJ |
| 刊名 | CHEMICO-BIOLOGICAL INTERACTIONS
 |
| 出版日期 | 2013 |
| 卷号 | 203期号:1页码:309-313 |
| 关键词 | Acetylcholinesterase (AChE) Glycogen synthase kinase-3 beta (GSK3 beta) HEK293T cells Proteasome |
| 通讯作者 | Zhang, XJ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, 320 YueYang Rd, Shanghai 200031, Peoples R China.,xjzhang@sibs.ac.cn |
| 英文摘要 | Lithium is one of the most widely used mood-stabilizing agents for the treatment of bipolar disorder. Lithium is also a potent inhibitor of glycogen synthase kinase-3 beta (GSK3 beta) activity, which is linked to Alzheimer's disease (AD). In experiments with cultured HEK293T cells, we show here that GSK3 beta stabilizes synaptic acetylcholinesterase (AChE-S), a critical component of AD development. Cells treated with lithium exhibited rapid proteasomal degradation of AChE-S. Furthermore treatment of the cells with MG 132, an inhibitor of the 265 proteasome, prevented the destabilizing effect of lithium on AChE-S. Taken together, these findings suggest that regulation of AChE-S protein stability may be an important biological target of lithium therapy. (C) 2012 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Toxicology |
| 关键词[WOS] | GLYCOGEN-SYNTHASE KINASE-3 ; ALZHEIMERS-DISEASE ; INDUCED APOPTOSIS ; N-GLYCOSYLATION ; PROTEIN-KINASE ; PHOSPHORYLATION ; CELLS ; CHOLINESTERASES ; SIALYLATION ; INDUCTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000318201800061 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/314]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Jing, P,Zhang, JY,Ouyang, Q,et al. Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3 beta[J]. CHEMICO-BIOLOGICAL INTERACTIONS,2013,203(1):309-313. |
| APA | Jing, P,Zhang, JY,Ouyang, Q,Wu, J,&Zhang, XJ.(2013).Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3 beta.CHEMICO-BIOLOGICAL INTERACTIONS,203(1),309-313. |
| MLA | Jing, P,et al."Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3 beta".CHEMICO-BIOLOGICAL INTERACTIONS 203.1(2013):309-313. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。