SREBP: a novel therapeutic target
文献类型：期刊论文
| 作者 | Xiao, X; Song, BL |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2013 |
| 卷号 | 45期号:1页码:42045 |
| 关键词 | SREBP insulin cAMP vitamin A miRNA therapeutic target |
| 通讯作者 | Xiao, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,xiaoxu@sibcb.ac.cn |
| 英文摘要 | Sterol regulatory element-binding proteins (SREBPs) are major transcription factors regulating the biosynthesis of cholesterol, fatty acid, and triglyceride. They control the expression of crucial genes involved in lipogenesis and uptake. In this review, we summarize the processing of SREBPs and their regulation by insulin, cAMP, and vitamin A, and the relationship between miRNA and lipid metabolism. We also discuss the recent functional studies on SREBPs. These discoveries suggest that inhibition of SREBP can be a novel strategy to treat metabolic diseases, such as type II diabetes, insulin resistance, fatty liver, and atherosclerosis. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | ELEMENT-BINDING PROTEIN-1C ; HMG-COA REDUCTASE ; LIVER-X-RECEPTOR ; FATTY-ACID SYNTHESIS ; NECROSIS-FACTOR-ALPHA ; CHOLESTEROL HOMEOSTASIS ; ENDOPLASMIC-RETICULUM ; INSULIN-RESISTANCE ; LIPID-METABOLISM ; COPII PROTEINS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000312640100002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/328]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xiao, X,Song, BL. SREBP: a novel therapeutic target[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2013,45(1):42045. |
| APA | Xiao, X,&Song, BL.(2013).SREBP: a novel therapeutic target.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,45(1),42045. |
| MLA | Xiao, X,et al."SREBP: a novel therapeutic target".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 45.1(2013):42045. |
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