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Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition
文献类型：期刊论文
| 作者 | Zhang, RR; Cui, QY; Murai, K; Lim, YC; Smith, ZD; Jin, SN; Ye, P; Rosa, L; Lee, YK; Wu, HP |
| 刊名 | CELL STEM CELL
 |
| 出版日期 | 2013 |
| 卷号 | 13期号:2页码:237-245 |
| 通讯作者 | Ding, CM (reprint author), Agcy Sci Technol & Res, Singapore Inst Clin Sci, Singapore 117609, Singapore.,ding_chunming@sics.a-star.edu.sg ; yshi@coh.org ; glxu@sibs.ac.cn |
| 英文摘要 | DNA hydroxylation catalyzed by Tet dioxygenases occurs abundantly in embryonic stem cells and neurons in mammals. However, its biological function in vivo is largely unknown. Here, we demonstrate that Tet1 plays an important role in regulating neural progenitor cell proliferation in adult mouse brain. Mice lacking Tet1 exhibit impaired hippocampal neurogenesis accompanied by poor learning and memory. In adult neural progenitor cells deficient in Tet1, a cohort of genes involved in progenitor proliferation were hypermethylated and downregulated. Our results indicate that Tet1 is positively involved in the epigenetic regulation of neural progenitor cell proliferation in the adult brain. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell & Tissue Engineering ; Cell Biology |
| 关键词[WOS] | ACTIVE DNA DEMETHYLATION ; EMBRYONIC STEM-CELLS ; POSTNATAL-DEVELOPMENT ; GENE-EXPRESSION ; MAMMALIAN DNA ; NEURAL STEM ; 5-HYDROXYMETHYLCYTOSINE ; BRAIN ; NEURONS ; 5-METHYLCYTOSINE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000329570600016 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/330]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, RR,Cui, QY,Murai, K,et al. Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition[J]. CELL STEM CELL,2013,13(2):237-245. |
| APA | Zhang, RR.,Cui, QY.,Murai, K.,Lim, YC.,Smith, ZD.,...&Xu, GL.(2013).Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition.CELL STEM CELL,13(2),237-245. |
| MLA | Zhang, RR,et al."Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition".CELL STEM CELL 13.2(2013):237-245. |
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