Tet1 is required for Rb phosphorylation during G1/S phase transition
文献类型：期刊论文
| 作者 | Huang, SS; Zhu, ZQ; Wang, YQ; Wang, YR; Xu, LX; Chen, XM; Xu, Q; Zhang, QM; Zhao, X; Yu, Y |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2013 |
| 卷号 | 434期号:2页码:241-244 |
| 关键词 | Tet1 Hydroxylase Rb phosphorylation Cyclin D1 G1/S phase entry |
| 通讯作者 | Wu, DL (reprint author), Tongji Hosp, Dept Urol, 389 Xincun Rd, Shanghai 200065, Peoples R China.,yuyi@sibcb.ac.cn ; wudenglong@163.com |
| 英文摘要 | DNA methylation plays an important role in many biological processes, including regulation of gene expression, maintenance of chromatin conformation and genomic stability. TET-family proteins convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), which indicates that these enzymes may participate in DNA demethylation. The function of TET1 has not yet been well characterized in somatic cells. Here, we show that depletion of Tet1 in NIH3T3 cells inhibits cell growth. Furthermore, Tet1 knockdown blocks cyclin D1 accumulation in G1 phase, inhibits Rb phosphorylation and consequently delays entrance to G1/S phase. Taken together, this study demonstrates that Tet1 is required for cell proliferation and that this process is mediated through the Rb pathway. (c) 2013 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | ACUTE MYELOID-LEUKEMIA ; ACTIVE DNA DEMETHYLATION ; EMBRYONIC STEM-CELLS ; CANCER ; EPIGENETICS ; MUTATIONS ; METHYLATION ; MLL ; 5-HYDROXYMETHYLCYTOSINE ; T(10/11)(Q22,Q23) |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000319098800010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/336]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Huang, SS,Zhu, ZQ,Wang, YQ,et al. Tet1 is required for Rb phosphorylation during G1/S phase transition[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,434(2):241-244. |
| APA | Huang, SS.,Zhu, ZQ.,Wang, YQ.,Wang, YR.,Xu, LX.,...&Wu, DL.(2013).Tet1 is required for Rb phosphorylation during G1/S phase transition.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,434(2),241-244. |
| MLA | Huang, SS,et al."Tet1 is required for Rb phosphorylation during G1/S phase transition".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 434.2(2013):241-244. |
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