Sevoflurane Combined with ATP Activates Caspase-1 and Triggers Caspase-1-Dependent Pyroptosis in Murine J774 Macrophages
文献类型：期刊论文
| 作者 | Jin, Y; Li, H; Xie, GH; Chen, SZ; Wu, SJ; Fang, XM |
| 刊名 | INFLAMMATION
 |
| 出版日期 | 2013 |
| 卷号 | 36期号:2页码:330-336 |
| 关键词 | sevoflurane caspase-1 pyroptosis ROS |
| 通讯作者 | Fang, XM (reprint author), Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Anesthesiol, QingChun Rd 79, Hangzhou 310003, Zhejiang, Peoples R China.,xiangming_fang@163.com |
| 英文摘要 | Sevoflurane is one of the most commonly used volatile anesthetics. Recent studies have shown that sevoflurane plays an important role in modulation of inflammation and immunity. However, little is known about the related molecular mechanisms. This study was designed to investigate the effects and mechanisms of sevoflurane on inflammatory cell death pyroptosis in the murine macrophage cell line J774 cells. Sevoflurane combined with ATP could increase the level of activated caspase-1, pyroptosis, and reactive oxygen species (ROS). Furthermore, treatment of cells with the caspase-1 inhibitor Ac-YVAD-CMK dramatically decreased the percentage of pyroptosis. In addition, inhibition of ROS with N-acetyl-l-cysteine or diphenyleneiodonium significantly reduced the activated levels of caspase-1. These results demonstrated that sevoflurane combined with ATP could activate caspase-1 and trigger caspase-1-dependent pyroptosis through the modulation of ROS production. |
| 学科主题 | Cell Biology; Immunology |
| 类目[WOS] | Cell Biology ; Immunology |
| 关键词[WOS] | INFLAMMASOME ACTIVATION ; NALP3 INFLAMMASOME ; OXIDATIVE STRESS ; CELLS ; CARDIOPROTECTION ; PATHOGENESIS ; IL-1-BETA ; AUTOCRINE ; SECRETION ; MECHANISM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000316020100009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/338]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Jin, Y,Li, H,Xie, GH,et al. Sevoflurane Combined with ATP Activates Caspase-1 and Triggers Caspase-1-Dependent Pyroptosis in Murine J774 Macrophages[J]. INFLAMMATION,2013,36(2):330-336. |
| APA | Jin, Y,Li, H,Xie, GH,Chen, SZ,Wu, SJ,&Fang, XM.(2013).Sevoflurane Combined with ATP Activates Caspase-1 and Triggers Caspase-1-Dependent Pyroptosis in Murine J774 Macrophages.INFLAMMATION,36(2),330-336. |
| MLA | Jin, Y,et al."Sevoflurane Combined with ATP Activates Caspase-1 and Triggers Caspase-1-Dependent Pyroptosis in Murine J774 Macrophages".INFLAMMATION 36.2(2013):330-336. |
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