Acetylcholinesterase deficiency decreases apoptosis in dopaminergic neurons in the neurotoxin model of Parkinson's disease
文献类型：期刊论文
| 作者 | Zhang, XJ; Lu, L; Liu, SJ; Ye, WY; Wu, J; Zhang, XJ |
| 刊名 | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
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| 出版日期 | 2013 |
| 卷号 | 45期号:2页码:265-272 |
| 关键词 | Acetylcholinesterase Parkinson's disease Apoptosis Dopaminergic neurons |
| 通讯作者 | Zhang, XJ (reprint author), Chinese Acad Sci, Grad Sch, State Key Lab Cell Biol, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, 320 YueYang Rd, Shanghai 200031, Peoples R China.,xjzhang@sibcb.ac.cn |
| 英文摘要 | The apoptosis pathway has been proposed to be involved in causing neuronal cell death in the pathogenesis of Parkinson's disease. However, the details of this pathway are poorly understood. Previous research has shown increased acetylcholinesterase expression during apoptosis in various cell types, which suggests that acetylcholinesterase has a potential role in neuronal cell death. In this study, we found that acetylcholinesterase protein expression increased and caspase-3 was activated in PC12 cells treated with 1-methyl-4-phenylpyridinium. Furthermore, the genetic or pharmacological inhibition of acetylcholinesterase was shown to protect PC12 cells from MPP+ induced apoptotic cell death. To study the function of acetylcholinesterase as a mechanism of neuronal cell death in vivo, we subsequently established a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Parkinson's disease mouse model utilizing acetylcholinesterase-deficient mice. Studies in these mice revealed reduced dopaminergic neuron loss and lower expression levels of apoptotic proteins in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated heterozygous mice compared to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated wild-type mice. We conclude that it is highly probable that acetylcholinesterase is involved in the pathogenesis of the neurotoxin model of Parkinson's disease via apoptosis. Specifically, a deficiency or inhibition of acetylcholinesterase can decrease apoptosis and protect dopaminergic neurons in the neurotoxin model of Parkinson's disease. (C) 2012 Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | CELL-DEATH ; PC12 CELLS ; SUBSTANTIA-NIGRA ; EXPRESSION ; DONEPEZIL ; GROWTH ; INHIBITION ; RECEPTORS ; INDUCTION ; RELEVANCE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000315251500007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/341]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, XJ,Lu, L,Liu, SJ,et al. Acetylcholinesterase deficiency decreases apoptosis in dopaminergic neurons in the neurotoxin model of Parkinson's disease[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,2013,45(2):265-272. |
| APA | Zhang, XJ,Lu, L,Liu, SJ,Ye, WY,Wu, J,&Zhang, XJ.(2013).Acetylcholinesterase deficiency decreases apoptosis in dopaminergic neurons in the neurotoxin model of Parkinson's disease.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,45(2),265-272. |
| MLA | Zhang, XJ,et al."Acetylcholinesterase deficiency decreases apoptosis in dopaminergic neurons in the neurotoxin model of Parkinson's disease".INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 45.2(2013):265-272. |
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