Cell fate conversion: Direct induction of hepatocyte-like cells from fibroblasts
文献类型：期刊论文
| 作者 | Ji, SY; Zhang, LD; Hui, LJ |
| 刊名 | JOURNAL OF CELLULAR BIOCHEMISTRY
 |
| 出版日期 | 2013 |
| 卷号 | 114期号:2页码:256-265 |
| 关键词 | INDUCED HEPATOCYTE-LIKE CELLS CELL FATE CONVERSION p19Arf/p53 |
| 通讯作者 | Hui, LJ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Yueyang Rd 320, Shanghai 200031, Peoples R China.,ljhui@sibs.ac.cn |
| 英文摘要 | One of the essential features of stem cells is their cellular plasticity to differentiate into daughter cells with defined functions. Recently, induction of pluripotent stem cells from somatic cells by defined transcription factors led to the focus on cellular plasticity of terminally differentiated cells. This approach is adopted by other studies to demonstrate the cell fate conversion between different lineages of terminally differentiated cells. We and others showed that induced hepatocyte-like (iHep) cells are directly converted from mouse fibroblasts by overexpression of liver-enriched transcription factors. iHep cells as well as pluripotent stem cell- or mesenchymal stem cell-derived hepatocyte-like cells provide potential cell sources for disease modeling, transplantation, and tissue engineering independent of donor organs. Here, we review the latest advances in generating hepatocyte-like cells and summarize general criteria for evaluating these cells. In addition, we propose a possible role of the p19Arf/p53 pathway in cell fate maintenance, which apparently limits the formation of induced pluripotent stem (iPS) cells and iHep cells. J. Cell. Biochem. 114: 256265, 2013. (c) 2012 Wiley Periodicals, Inc. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | EMBRYONIC STEM-CELLS ; IN-VITRO DIFFERENTIATION ; ADULT BONE-MARROW ; DEFINED FACTORS ; EFFICIENT DIFFERENTIATION ; DEFINITIVE ENDODERM ; TUMOR-SUPPRESSOR ; ADIPOSE-TISSUE ; HEPATIC DIFFERENTIATION ; FUNCTIONAL HEPATOCYTES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000312651400003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/344]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Ji, SY,Zhang, LD,Hui, LJ. Cell fate conversion: Direct induction of hepatocyte-like cells from fibroblasts[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2013,114(2):256-265. |
| APA | Ji, SY,Zhang, LD,&Hui, LJ.(2013).Cell fate conversion: Direct induction of hepatocyte-like cells from fibroblasts.JOURNAL OF CELLULAR BIOCHEMISTRY,114(2),256-265. |
| MLA | Ji, SY,et al."Cell fate conversion: Direct induction of hepatocyte-like cells from fibroblasts".JOURNAL OF CELLULAR BIOCHEMISTRY 114.2(2013):256-265. |
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