Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient
文献类型：期刊论文
| 作者 | Hu, WB; Chen, AZ; Miao, Y; Xia, SL; Ling, ZY; Xu, K; Wang, TY; Xu, Y; Cui, J; Wu, HQ |
| 刊名 | VIROLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 435期号:2页码:320-328 |
| 关键词 | Influenza H1N1 Fully human monoclonal antibody Neutralization Epitope HA2 Single-cell RT-PCR Fusion peptide |
| 通讯作者 | Lin, XJ (reprint author), 320 Yueyang Rd, Shanghai 200031, Peoples R China.,linxiaojun@hualan.com ; cbian@sibs.ac.cn ; bsun@sibs.ac.cn |
| 英文摘要 | Whether the 2009 pandemic HI NI influenza vaccine can induce heterosubtypic cross-protective anti-hemagglutinin (HA) neutralizing antibodies is an important issue. We obtained a panel of fully human monoclonal antibodies from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient. Most of the monoclonal antibodies targeted the HA protein but not the HA1 fragment. Among the analyzed antibodies, seven mAbs exhibited neutralizing activity against several influenza A viruses of different subtypes. The conserved linear epitope targeted by the neutralizing mAbs (FIEGGWTGMVDG-WYGYHH) is part of the fusion peptide on HA2. Our work suggests that a heterosubtypic neutralizing antibody response primarily targeting the HA stem region exists in recipients of the 2009 pandemic H1N1 influenza vaccine. The HA stem region contains various conserved neutralizing epitopes with the fusion peptide as an important one. This work may aid in the design of a universal influenza A virus vaccine. (C) 2012 Elsevier Inc. All rights reserved. |
| 学科主题 | Virology |
| 类目[WOS] | Virology |
| 关键词[WOS] | MEMBRANE-FUSION ; HEMAGGLUTININ ; H5N1 ; INFECTION ; EPITOPE ; MICE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000313459200014 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/345]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Hu, WB,Chen, AZ,Miao, Y,et al. Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient[J]. VIROLOGY,2013,435(2):320-328. |
| APA | Hu, WB.,Chen, AZ.,Miao, Y.,Xia, SL.,Ling, ZY.,...&Sun, B.(2013).Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient.VIROLOGY,435(2),320-328. |
| MLA | Hu, WB,et al."Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient".VIROLOGY 435.2(2013):320-328. |
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