Negative regulation of NLRP3 inflammasome signaling
文献类型：期刊论文
| 作者 | Chen, SZ; Sun, B |
| 刊名 | PROTEIN & CELL
 |
| 出版日期 | 2013 |
| 卷号 | 4期号:4页码:251-258 |
| 关键词 | inflammasome NLRP3 negative regulation inflammation |
| 通讯作者 | Sun, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,bsun@sibs.ac.cn |
| 英文摘要 | Inflammasomes are multiprotein complexes that serve as a platform for caspase-1 activation and interleukin-1 beta (IL-1 beta) maturation as well as pyroptosis. Though a number of inflammasomes have been described, the NLRP3 inflammasome is the most extensively studied. NLRP3 inflammasome is triggered by a variety of stimuli, including infection, tissue damage and metabolic dysregulation, and then activated through an integrated cellular signal. Many regulatory mechanisms have been identified to attenuate NLRP3 inflammasome signaling at multiple steps. Here, we review the developments in the negative regulation of NLRP3 inflammasome that protect host from inflammatory damage. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | COLD AUTOINFLAMMATORY SYNDROME ; ADAPTIVE IMMUNE-RESPONSES ; NITRIC-OXIDE ; NALP3 INFLAMMASOME ; IL-1-BETA PRODUCTION ; INTERLEUKIN-1-BETA GENERATION ; CYTOPLASMIC DNA ; DOMAIN PROTEIN ; URIC-ACID ; ACTIVATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000317018000003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/381]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Chen, SZ,Sun, B. Negative regulation of NLRP3 inflammasome signaling[J]. PROTEIN & CELL,2013,4(4):251-258. |
| APA | Chen, SZ,&Sun, B.(2013).Negative regulation of NLRP3 inflammasome signaling.PROTEIN & CELL,4(4),251-258. |
| MLA | Chen, SZ,et al."Negative regulation of NLRP3 inflammasome signaling".PROTEIN & CELL 4.4(2013):251-258. |
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