Lmx1b controls peptide phenotypes in serotonergic and dopaminergic neurons
文献类型：期刊论文
| 作者 | Yan, R; Huang, TW; Xie, ZQ; Xia, GN; Qian, H; Zhao, XL; Cheng, LP |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2013 |
| 卷号 | 45期号:5页码:345-352 |
| 关键词 | Lmx1b neurotransmitter peptide serotonergic neuron dopaminergic neuron |
| 通讯作者 | Cheng, LP (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,lpcheng@ion.ac.cn |
| 英文摘要 | Serotonin (5-HT) neurons synthesize a variety of peptides. How these peptides are controlled during development remains unclear. It has been reported that the co-localization of peptides and 5-HT varies by species. In contrast to the situations in the rostral 5-HT neurons of human and rat brains, several peptides do not coexist with 5-HT in the rostral 5-HT neurons of mouse brain. In this study, we found that the peptide substance P and peptide genes, including those encoding peptides thyrotropin-releasing hormone, enkephalin, and calcitonin gene-related peptide, were expressed in the caudal 5-HT neurons of mouse brain; these findings are in line with observations in rat and monkey 5-HT neurons. We also revealed that these peptides/peptide genes partially overlapped with the transcription factor Lmx1b that specifies the 5-HT cell fate. Furthermore, we found that the peptide cholecystokinin was expressed in developing dopaminergic neurons and greatly overlapped with Lmx1b that specifies the dopaminergic cell fate. By examining the phenotype of Lmx1b deletion mice, we found that Lmx1b was required for the expression of above peptides expressed in 5-HT or dopaminergic neurons. Together, our results indicate that Lmx1b, a key transcription factor for the specification of 5-HT and dopaminergic transmitter phenotypes during embryogenesis, determines some peptide phenotypes in these neurons as well. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | CENTRAL-NERVOUS-SYSTEM ; SUBSTANCE P-LIKE ; SPINAL-CORD ; NEURAL CREST ; CELL-BODIES ; RAT ; COEXISTENCE ; BRAIN ; IMMUNOREACTIVITY ; SPECIFICATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000318084700001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/389]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yan, R,Huang, TW,Xie, ZQ,et al. Lmx1b controls peptide phenotypes in serotonergic and dopaminergic neurons[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2013,45(5):345-352. |
| APA | Yan, R.,Huang, TW.,Xie, ZQ.,Xia, GN.,Qian, H.,...&Cheng, LP.(2013).Lmx1b controls peptide phenotypes in serotonergic and dopaminergic neurons.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,45(5),345-352. |
| MLA | Yan, R,et al."Lmx1b controls peptide phenotypes in serotonergic and dopaminergic neurons".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 45.5(2013):345-352. |
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