Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-delta
文献类型：期刊论文
| 作者 | Do-Umehara, HC; Chen, C; Urich, D; Zhou, L; Qiu, J; Jang, S; Zander, A; Baker, MA; Eilers, M; Sporn, PHS |
| 刊名 | NATURE IMMUNOLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 14期号:5页码:461-461 |
| 通讯作者 | Liu, J (reprint author), Northwestern Univ, Feinberg Sch Med, Div Pulm & Crit Care Med, Chicago, IL 60611 USA.,jing@northwestern.edu |
| 英文摘要 | Inflammation is essential for host defense but can cause tissue damage and organ failure if unchecked. How the inflammation is resolved remains elusive. Here we report that the transcription factor Miz1 was required for terminating lipopolysaccharide (LPS)-induced inflammation. Genetic disruption of the Miz1 POZ domain, which is essential for the transactivation or repression activity of Miz1, resulted in hyperinflammation, lung injury and greater mortality in LPS-treated mice but a lower bacterial load and mortality in mice with Pseudomonas aeruginosa pneumonia. Loss of the Miz1 POZ domain prolonged the expression of proinflammatory cytokines. After stimulation, Miz1 was phosphorylated at Ser178, which was required for recruitment of the histone deacetylase HDAC1 to repress transcription of the gene encoding C/EBP-delta, an amplifier of inflammation. Our data provide a long-sought mechanism underlying the resolution of LPS-induced inflammation. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | NF-KAPPA-B ; TRANSCRIPTION FACTOR MIZ-1 ; INDUCED JNK ACTIVATION ; IMMUNE-RESPONSE ; GENETIC-CONTROL ; RECEPTOR ; MICE ; MYC ; ASSOCIATION ; APOPTOSIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000317732100011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/391]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Do-Umehara, HC,Chen, C,Urich, D,et al. Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-delta[J]. NATURE IMMUNOLOGY,2013,14(5):461-461. |
| APA | Do-Umehara, HC.,Chen, C.,Urich, D.,Zhou, L.,Qiu, J.,...&Liu, J.(2013).Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-delta.NATURE IMMUNOLOGY,14(5),461-461. |
| MLA | Do-Umehara, HC,et al."Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-delta".NATURE IMMUNOLOGY 14.5(2013):461-461. |
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