Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins
文献类型：期刊论文
| 作者 | Liu, X; Wang, Q; Chen, W; Wang, C |
| 刊名 | CYTOKINE & GROWTH FACTOR REVIEWS
 |
| 出版日期 | 2013 |
| 卷号 | 24期号:6页码:559-570 |
| 关键词 | Ubiquitin SUMO ISG15 Signal transduction Innate immunity |
| 通讯作者 | Wang, C (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,cwang01@sibcb.ac.cn |
| 英文摘要 | Protein post-translational modifications (PTMs) are central to the host innate immune regulations. Dynamically, PTMs fine-tune the spatial and temporary responses of immune- and non-immune-cells, in accordance with extracellular and intracellular stresses. Ubiquitin and ubiquitin-like proteins (Ubls) are emerging as the important multi-functional signals, controlling the activation, stability, affinity and location of many signaling proteins. Recent investigations, at the molecular-cellular-animal models, have shed new light on the versatility of the ubiquitin, SUMO and ISG15, for shaping the strength and duration of the innate immune responses. This review summarizes our current knowledge on the functions and regulatory mechanisms of the ubiquitin and Ubls in the innate immunity, the first line of host defense against microbial infection. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | NF-KAPPA-B ; I INTERFERON INDUCTION ; CELLULAR ANTIVIRAL RESPONSE ; UNANCHORED POLYUBIQUITIN CHAINS ; PATTERN-RECOGNITION RECEPTORS ; TOLL-LIKE RECEPTORS ; NOD-LIKE RECEPTORS ; RIG-I ; NEGATIVE REGULATION ; KINASE COMPLEX |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000328923900007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/400]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, X,Wang, Q,Chen, W,et al. Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins[J]. CYTOKINE & GROWTH FACTOR REVIEWS,2013,24(6):559-570. |
| APA | Liu, X,Wang, Q,Chen, W,&Wang, C.(2013).Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins.CYTOKINE & GROWTH FACTOR REVIEWS,24(6),559-570. |
| MLA | Liu, X,et al."Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins".CYTOKINE & GROWTH FACTOR REVIEWS 24.6(2013):559-570. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。