Generating Hypoimmunogenic Human Embryonic Stem Cells by the Disruption of Beta 2-Microglobulin
文献类型：期刊论文
| 作者 | Lu, PF; Chen, JJ; He, LXZ; Ren, JT; Chen, HD; Rao, LJ; Zhuang, QG; Li, H; Li, L; Bao, L |
| 刊名 | STEM CELL REVIEWS AND REPORTS
 |
| 出版日期 | 2013 |
| 卷号 | 9期号:6页码:806-813 |
| 关键词 | Beta 2-microglobulin Human leukocyte antigens Hypoimmunogenicity Human embryonic stem cells Immune rejection iPS cells |
| 通讯作者 | Xiao, L (reprint author), Zhejiang Univ, Sch Med, 866 Yuhangtang Rd,Nongshenghuan Bldg E,Room 301, Hangzhou 310058, Zhejiang, Peoples R China.,leixiao@sibs.ac.cn |
| 英文摘要 | Immune rejection hinders the application of human embryonic stem cells (hESCs) in transplantation therapy. Human leukocyte antigens (HLAs) on the cell surface are the major cause of graft rejection. In this study, we generated HLA class I-deficient hESCs via disruption of beta 2-microglobulin (beta 2m), the light chain of HLA Class I. We found that HLA class I proteins were not present on the cell surface of beta 2m-null hESCs. These cells showed the same pluripotency as wildtype hESCs and demonstrated hypoimmunogenicity. Thus, HLA class I-deficient hESCs might serve as an unlimited cell source for the generation of universally compatible "off-the-shelf" cell grafts, tissues or organs in the future. |
| 学科主题 | Cell Biology; Research & Experimental Medicine |
| 类目[WOS] | Cell & Tissue Engineering ; Cell Biology ; Medicine, Research & Experimental |
| 关键词[WOS] | NATURAL-KILLER-CELLS ; T-CELLS ; LINES ; DEFICIENT ; EFFECTORS ; PROTEINS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000327386500007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/402]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Lu, PF,Chen, JJ,He, LXZ,et al. Generating Hypoimmunogenic Human Embryonic Stem Cells by the Disruption of Beta 2-Microglobulin[J]. STEM CELL REVIEWS AND REPORTS,2013,9(6):806-813. |
| APA | Lu, PF.,Chen, JJ.,He, LXZ.,Ren, JT.,Chen, HD.,...&Xiao, L.(2013).Generating Hypoimmunogenic Human Embryonic Stem Cells by the Disruption of Beta 2-Microglobulin.STEM CELL REVIEWS AND REPORTS,9(6),806-813. |
| MLA | Lu, PF,et al."Generating Hypoimmunogenic Human Embryonic Stem Cells by the Disruption of Beta 2-Microglobulin".STEM CELL REVIEWS AND REPORTS 9.6(2013):806-813. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。