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Circular Intronic Long Noncoding RNAs
文献类型：期刊论文
| 作者 | Zhang, Y; Zhang, XO; Chen, T; Xiang, JF; Yin, QF; Xing, YH; Zhu, SS; Yang, L; Chen, LL |
| 刊名 | MOLECULAR CELL
 |
| 出版日期 | 2013 |
| 卷号 | 51期号:6页码:792-806 |
| 通讯作者 | Yang, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200031, Peoples R China.,liyang@picb.ac.cn ; linglingchen@sibcb.ac.cn |
| 英文摘要 | We describe the identification and characterization of circular intronic long noncoding RNAs in human cells, which accumulate owing to a failure in debranching. The formation of such circular intronic RNAs (ciRNAs) can be recapitulated using expression vectors, and their processing depends on a consensus motif containing a 7 nt GU-rich element near the 50 splice site and an 11 nt C-rich element close to the branchpoint site. In addition, we show that ciRNAs are abundant in the nucleus and have little enrichment for microRNA target sites. Importantly, knockdown of ciRNAs led to the reduced expression of their parent genes. One abundant such RNA, ci-ankrd52, largely accumulates to its sites of transcription, associates with elongation Pol II machinery, and acts as a positive regulator of Pol II transcription. This study thus suggests a cis-regulatory role of noncoding intronic transcripts on their parent coding genes. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | SMALL NUCLEOLAR RNAS ; POLYMERASE-II ; B2 RNA ; PROTEIN INTERACTIONS ; REGULATORY RNAS ; ANKYRIN REPEAT ; TRANSCRIPTION ; REVEALS ; CELLS ; GENE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330191200009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/403]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Y,Zhang, XO,Chen, T,et al. Circular Intronic Long Noncoding RNAs[J]. MOLECULAR CELL,2013,51(6):792-806. |
| APA | Zhang, Y.,Zhang, XO.,Chen, T.,Xiang, JF.,Yin, QF.,...&Chen, LL.(2013).Circular Intronic Long Noncoding RNAs.MOLECULAR CELL,51(6),792-806. |
| MLA | Zhang, Y,et al."Circular Intronic Long Noncoding RNAs".MOLECULAR CELL 51.6(2013):792-806. |
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