Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7
文献类型：期刊论文
| 作者 | Wang, J; Yang, B; Hu, Y; Zheng, YH; Zhou, HY; Wang, YM; Ma, YL; Mao, KR; Yang, LL; Lin, GM |
| 刊名 | JOURNAL OF IMMUNOLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 191期号:6页码:3393-3399 |
| 通讯作者 | Sun, B (reprint author), Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,wxd@sibs.ac.cn ; bsun@sibs.ac.cn |
| 英文摘要 | Viral infection causes host cells to produce type I IFNs, which play a critical role in viral clearance. IFN regulatory factor (IRF) 7 is the master regulator of type I IFN-dependent immune responses. In this article, we report that N-Myc and STATs interactor (Nmi), a Sendai virus-inducible protein, interacted with IRF7 and inhibited virus-triggered type I IFN production. The overexpression of Nmi inhibited the Sendai virus-triggered induction of type I IFNs, whereas the knockdown of Nmi promoted IFN production. Furthermore, the enhanced production of IFNs resulting from Nmi knockdown was sufficient to protect cells from infection by vesicular stomatitis virus. In addition, Nmi was found to promote the K48-linked ubiquitination of IRF7 and the proteasome-dependent degradation of this protein. Finally, an impairment of antiviral responses is also detectable in Nmi-transgenic mice. These findings suggest that Nmi is a negative regulator of the virus-triggered induction of type I IFNs that targets IRF7. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | INTERACTING PROTEIN NMI ; NF-KAPPA-B ; ANTIVIRAL RESPONSE ; TRANSCRIPTION FACTOR ; ADAPTER PROTEIN ; INTERFERON ; MYC ; PATHWAY ; IFP35 ; TRAF3 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000324206900057 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/404]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, J,Yang, B,Hu, Y,et al. Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7[J]. JOURNAL OF IMMUNOLOGY,2013,191(6):3393-3399. |
| APA | Wang, J.,Yang, B.,Hu, Y.,Zheng, YH.,Zhou, HY.,...&Sun, B.(2013).Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7.JOURNAL OF IMMUNOLOGY,191(6),3393-3399. |
| MLA | Wang, J,et al."Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7".JOURNAL OF IMMUNOLOGY 191.6(2013):3393-3399. |
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