Cellular localization of NLRP3 inflammasome
文献类型：期刊论文
| 作者 | Wang, Y; Yang, C; Mao, KR; Chen, SZ; Meng, GX; Sun, B |
| 刊名 | PROTEIN & CELL
 |
| 出版日期 | 2013 |
| 卷号 | 4期号:6页码:425-431 |
| 关键词 | NLRP3 infl ammasome ASC pyroptosome confocal microscopy cytoplasmic |
| 通讯作者 | Meng, GX (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Shanghai 200025, Peoples R China.,gxmeng@sibs.ac.cn ; bsun@sibs.ac.cn |
| 英文摘要 | Inflammasome is a large protein complex activated upon cellular stress or microbial infection, which triggers maturation of pro-inflammatory cytokines interleukin-1 beta and interleukin-18 through caspase-1 activation. Nod-like receptor family protein 3 (NLRP3) is the most characterized inflammasome activated by various stimuli. However, the mechanism of its activation is unclear and its exact cellular localization is still unknown. We examined the potential co-localization of NLRP3 inflammasome with mitochondria and seven other organelles under adenosine triphosphate, nigericin or monosodium urate stimulation in mouse peritoneal macrophages using confocal microscopy approach. Our results revealed that the activated endogenous apoptosis-associated speck-like protein containing a CARD (ASC) pyroptosome forms in the cytoplasm and co-localizes with NLRP3 and caspase-1, but not with any of the organelles screened. This study indicates that the ASC pyroptosome universally localizes within the cytoplasm rather than with any specific organelles. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | CASPASE RECRUITMENT DOMAIN ; SPECK-LIKE PROTEIN ; NALP3 INFLAMMASOME ; ACTIVATION ; ASC ; CRYSTALS ; DEATH ; CELLS ; BETA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000320329700003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/408]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Y,Yang, C,Mao, KR,et al. Cellular localization of NLRP3 inflammasome[J]. PROTEIN & CELL,2013,4(6):425-431. |
| APA | Wang, Y,Yang, C,Mao, KR,Chen, SZ,Meng, GX,&Sun, B.(2013).Cellular localization of NLRP3 inflammasome.PROTEIN & CELL,4(6),425-431. |
| MLA | Wang, Y,et al."Cellular localization of NLRP3 inflammasome".PROTEIN & CELL 4.6(2013):425-431. |
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