A Newly Identified MicroRNA, mmu-miR-7578, Functions as a Negative Regulator on Inflammatory Cytokines Tumor Necrosis Factor-alpha and Interleukin-6 via Targeting Egr1 in Vivo
文献类型：期刊论文
| 作者 | Zhang, JS; Xie, SS; Ma, WB; Teng, Y; Tian, Y; Huang, XX; Zhang, YL |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
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| 出版日期 | 2013 |
| 卷号 | 288期号:6页码:4310-4320 |
| 通讯作者 | Huang, XX (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Key Lab Mol Androl, State Key Lab Mol Biol,Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,xingxuhuang@mail.nju.edu.cn ; ylzhang@sibcb.ac.cn |
| 英文摘要 | Appropriate innate immune responses are required to protect an organism against foreign pathogens, and the immune response must be tightly controlled. Here, we report a new microRNA (miRNA) identified from a small RNA library from the epididymis, termed miR-7578, that acts as a negative regulator of inflammatory responses. It was abundantly expressed in immune-related organs and induced by lipopolysaccharide in the lung and epididymis, as well as macrophages stimulated with diverse Toll-like receptor ligands, in an NF-kappa B-dependent manner. mmu-miR-7578 inhibited the release of pro-inflammatory cytokines, including TNF alpha and IL6, by regulating its target gene Egr1, which encodes a transcription factor that activates TNF alpha and NF-kappa B expression. Transgenic mice overexpressing mmu-miR-7578 displayed higher resistance to endotoxin shock and lower plasma levels of TNF alpha and IL6, indicating that this miRNA acted as a negative molecule of immune response. In sum, we report a previously uncharacterized LPS-responsive miRNA that controls inflammatory response in a feedback loop by fine-tuning a key transcription factor in vivo. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | INNATE IMMUNE-RESPONSES ; TRANSCRIPTION FACTORS ; POSSIBLE ROLES ; EXPRESSION ; EGR-1 ; CELLS ; INDUCTION ; MURINE ; LIPOPOLYSACCHARIDE ; STIMULATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000314845000059 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/410]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, JS,Xie, SS,Ma, WB,et al. A Newly Identified MicroRNA, mmu-miR-7578, Functions as a Negative Regulator on Inflammatory Cytokines Tumor Necrosis Factor-alpha and Interleukin-6 via Targeting Egr1 in Vivo[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2013,288(6):4310-4320. |
| APA | Zhang, JS.,Xie, SS.,Ma, WB.,Teng, Y.,Tian, Y.,...&Zhang, YL.(2013).A Newly Identified MicroRNA, mmu-miR-7578, Functions as a Negative Regulator on Inflammatory Cytokines Tumor Necrosis Factor-alpha and Interleukin-6 via Targeting Egr1 in Vivo.JOURNAL OF BIOLOGICAL CHEMISTRY,288(6),4310-4320. |
| MLA | Zhang, JS,et al."A Newly Identified MicroRNA, mmu-miR-7578, Functions as a Negative Regulator on Inflammatory Cytokines Tumor Necrosis Factor-alpha and Interleukin-6 via Targeting Egr1 in Vivo".JOURNAL OF BIOLOGICAL CHEMISTRY 288.6(2013):4310-4320. |
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