Hedgehog in the Drosophila testis niche: what does it do there?
文献类型：期刊论文
| 作者 | Zhang, Z; Pan, CY; Zhao, Y |
| 刊名 | PROTEIN & CELL
 |
| 出版日期 | 2013 |
| 卷号 | 4期号:9页码:650-655 |
| 关键词 | Drosophila testis stem cell Hedgehog JAK-STAT |
| 通讯作者 | Zhao, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,zhangzhao@sibcb.ac.cn ; yunzhao@sibcb.ac.cn |
| 英文摘要 | Stem cell niche is a specialized microenvironment crucial to self-renewal. The testis in Drosophila contains two different types of stem cells, the germline stem cells and the somatic cyst stem cells that are sustained by their respective niche signals, thus is a good system for studying the interaction between the stem cells and their hosting niche. The JAK-STAT and BMP pathways are known to play critical roles in the self-renewal of different kinds of stem cells, but the roles of several other pathways have emerged recently in a complex signaling network in the testis niche. Reports of independent observations from three research groups have uncovered an important role of Hedgehog (Hh) in the Drosophila testis niche. In this review, we summarize these recent findings and discuss the interplay between the Hh signaling mechanisms and those of the JAK-STAT and BMP pathways. We also discuss directions for further investigation. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | CELL SELF-RENEWAL ; SOMATIC STEM-CELLS ; CUBITUS-INTERRUPTUS ; TRANSCRIPTIONAL ACTIVATOR ; REQUIRES PHOSPHORYLATION ; PATHWAY ACTIVATION ; SIGNALING STRENGTH ; IMAGINAL DISKS ; PROTEIN-KINASE ; DUAL ROLES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000324102600003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/426]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Z,Pan, CY,Zhao, Y. Hedgehog in the Drosophila testis niche: what does it do there?[J]. PROTEIN & CELL,2013,4(9):650-655. |
| APA | Zhang, Z,Pan, CY,&Zhao, Y.(2013).Hedgehog in the Drosophila testis niche: what does it do there?.PROTEIN & CELL,4(9),650-655. |
| MLA | Zhang, Z,et al."Hedgehog in the Drosophila testis niche: what does it do there?".PROTEIN & CELL 4.9(2013):650-655. |
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