A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity
文献类型：期刊论文
| 作者 | Guo, T; Lu, Y; Li, PX; Yin, MX; Lv, DK; Zhang, WJ; Wang, HZ; Zhou, ZC; Ji, HB; Zhao, Y |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2013 |
| 卷号 | 23期号:10页码:1201-1214 |
| 关键词 | Hippo Sd |
| 通讯作者 | Zhang, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,yunzhao@sibcb.ac.cn ; rayzhang@sibcb.ac.cn |
| 英文摘要 | The Hippo (Hpo) pathway controls tissue growth and organ size by regulating the activity of transcriptional co-activator Yorkie (Yki), which associates with transcription factor Scalloped (Sd) in the nucleus to promote downstream target gene expression. Here we identify a novel protein Sd-Binding-Protein (SdBP)/Tgi, which directly competes with Yki for binding to Sd through its TDU domains and inhibits the Sd-Yki transcriptional activity. We also find that SdBP retains Yki in the nucleus through the association with Yki WW domains via its PPXY motifs. Collectively, we identify SdBP as a novel component of the Hpo pathway, negatively regulating the transcriptional activity of Sd-Yki to restrict tissue growth. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | TUMOR-SUPPRESSOR PATHWAY ; CELL-PROLIFERATION ; TRANSCRIPTION FACTOR ; PROMOTES APOPTOSIS ; GROWTH-CONTROL ; TISSUE-GROWTH ; CONTACT INHIBITION ; TEAD/TEF FAMILY ; GENE-EXPRESSION ; BANTAM MICRORNA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000325278000010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/434]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Guo, T,Lu, Y,Li, PX,et al. A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity[J]. CELL RESEARCH,2013,23(10):1201-1214. |
| APA | Guo, T.,Lu, Y.,Li, PX.,Yin, MX.,Lv, DK.,...&Zhang, L.(2013).A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity.CELL RESEARCH,23(10),1201-1214. |
| MLA | Guo, T,et al."A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity".CELL RESEARCH 23.10(2013):1201-1214. |
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