Transfer RNA: A dancer between charging and mis-charging for protein biosynthesis
文献类型：期刊论文
| 作者 | Zhou, XL; Wang, ED |
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2013 |
| 卷号 | 56期号:10页码:921-932 |
| 关键词 | tRNA aminoacyl-tRNA synthetase aminoacylation editing |
| 通讯作者 | Wang, ED (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Ctr RNA Res,State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,edwang@sibcb.ac.cn |
| 英文摘要 | Transfer RNA plays a fundamental role in the protein biosynthesis as an adaptor molecule by functioning as a biological link between the genetic nucleotide sequence in the mRNA and the amino acid sequence in the protein. To perform its role in protein biosynthesis, it has to be accurately recognized by aminoacyl-tRNA synthetases (aaRSs) to generate aminoacyl-tRNAs (aa-tRNAs). The correct pairing between an amino acid with its cognate tRNA is crucial for translational quality control. Production and utilization of mis-charged tRNAs are usually detrimental for all the species, resulting in cellular dysfunctions. Correct aa-tRNAs formation is collectively controlled by aaRSs with distinct mechanisms and/or other trans-factors. However, in very limited instances, mis-charged tRNAs are intermediate for specific pathways or essential components for the translational machinery. Here, from the point of accuracy in tRNA charging, we review our understanding about the mechanism ensuring correct aa-tRNA generation. In addition, some unique mis-charged tRNA species necessary for the organism are also briefly described. |
| 学科主题 | Life Sciences & Biomedicine - Other Topics |
| 类目[WOS] | Biology |
| 关键词[WOS] | AMINOACYL-TRANSFER-RNA ; MISCHARGED TRANSFER-RNA ; HAEMOPHILUS-INFLUENZAE YBAK ; RIBONUCLEIC-ACID SYNTHETASE ; QUALITY-CONTROL MECHANISMS ; ESCHERICHIA-COLI ; EDITING-DOMAIN ; GENETIC-CODE ; CRYSTAL-STRUCTURE ; STRUCTURAL BASIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000325252100009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/436]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhou, XL,Wang, ED. Transfer RNA: A dancer between charging and mis-charging for protein biosynthesis[J]. SCIENCE CHINA-LIFE SCIENCES,2013,56(10):921-932. |
| APA | Zhou, XL,&Wang, ED.(2013).Transfer RNA: A dancer between charging and mis-charging for protein biosynthesis.SCIENCE CHINA-LIFE SCIENCES,56(10),921-932. |
| MLA | Zhou, XL,et al."Transfer RNA: A dancer between charging and mis-charging for protein biosynthesis".SCIENCE CHINA-LIFE SCIENCES 56.10(2013):921-932. |
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