IFIT5 potentiates anti-viral response through enhancing innate immune signaling pathways
文献类型：期刊论文
| 作者 | Zhang, BH; Liu, XY; Chen, W; Chen, L |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2013 |
| 卷号 | 45期号:10页码:867-874 |
| 关键词 | IFIT5 IRF3 NF-B innate immune response |
| 通讯作者 | Zhang, BH (reprint author), E China Normal Univ, Shanghai Key Lab Regulatory Biol, Inst Biomed Sci, Sch Life Sci, Shanghai 200241, Peoples R China.,bhzhang@bio.ecnu.edu.cn |
| 英文摘要 | Humans have a distinct combination of IFIT (IFN-induced protein with tetratricopeptide repeats) family orthologs, including IFIT1 (ISG56), IFIT2 (ISG54), IFIT3 (ISG60), and IFIT5 (ISG58). The function of IFIT1/IFIT2/IFIT3 has been intensively investigated. However, little is known about the role of IFIT5 in any cellular processes. In this study, we reported that both the mRNA and protein levels of IFIT5 are up-regulated in response to RNA virus infection or polyinosiniccytidylic acid stimulation. Ectopic expression of IFIT5 could synergize IRF3- and NF-B-mediated gene expression, whereas knockdown of IFIT5 impairs the transcription of these genes. Consistently, anti-viral responses of host cells are significantly increased or decreased in the presence or absence of IFIT5. Mechanistically, IFIT5 co-localizes partly with mitochondria and interacts with RIG-I and MAVS. Our study identified that IFIT5 is an important enhancer in innate immune response. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | INTERFERON-STIMULATED GENES ; NF-KAPPA-B ; ADAPTER PROTEIN ; INDUCIBLE GENE ; FAMILY ; IDENTIFICATION ; RECOGNITION ; ACTIVATION ; VIRUS ; RNA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000324776700008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/437]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, BH,Liu, XY,Chen, W,et al. IFIT5 potentiates anti-viral response through enhancing innate immune signaling pathways[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2013,45(10):867-874. |
| APA | Zhang, BH,Liu, XY,Chen, W,&Chen, L.(2013).IFIT5 potentiates anti-viral response through enhancing innate immune signaling pathways.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,45(10),867-874. |
| MLA | Zhang, BH,et al."IFIT5 potentiates anti-viral response through enhancing innate immune signaling pathways".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 45.10(2013):867-874. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。