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Vitamin C modulates TET1 function during somatic cell reprogramming
文献类型：期刊论文
| 作者 | Chen, JK; Guo, L; Zhang, L; Wu, HY; Yang, JQ; Liu, H; Wang, XS; Hu, X; Gu, TP; Zhou, ZW |
| 刊名 | NATURE GENETICS
 |
| 出版日期 | 2013 |
| 卷号 | 45期号:12页码:1504-U140 |
| 通讯作者 | Xu, GL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Grp DNA Metab,State Key Lab Mol Biol, Shanghai, Peoples R China.,glxu@sibs.ac.cn ; pei_duanqing@gibh.ac.cn |
| 英文摘要 | Vitamin C, a micronutrient known for its anti-scurvy activity in humans, promotes the generation of induced pluripotent stem cells (iPSCs)(1) through the activity of histone demethylating dioxygenases(2,3). TET hydroxylases are also dioxygenases implicated in active DNA demethylation(4-8). Here we report that TET1 either positively or negatively regulates somatic cell reprogramming depending on the absence or presence of vitamin C. TET1 deficiency enhances reprogramming, and its overexpression impairs reprogramming in the context of vitamin C-2,C-9 by modulating the obligatory mesenchymal-to-epithelial transition (MET)(10,11). In the absence of vitamin C, TET1 promotes somatic cell reprogramming independent of MET. Consistently, TET1 regulates 5-hydroxymethylcytosine (5hmC) formation at loci critical for MET in a vitamin C-dependent fashion. Our findings suggest that vitamin C has a vital role in determining the biological outcome of TET1 function at the cellular level. Given its benefit to human health, vitamin C should be investigated further for its role in epigenetic regulation. |
| 学科主题 | Genetics & Heredity |
| 类目[WOS] | Genetics & Heredity |
| 关键词[WOS] | PLURIPOTENT STEM-CELLS ; LARGE GENE LISTS ; DNA DEMETHYLATION ; MAMMALIAN DNA ; MOUSE ; 5-HYDROXYMETHYLCYTOSINE ; GENERATION ; 5-METHYLCYTOSINE ; 5-CARBOXYLCYTOSINE ; SPECIFICATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000327715800020 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/449]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Chen, JK,Guo, L,Zhang, L,et al. Vitamin C modulates TET1 function during somatic cell reprogramming[J]. NATURE GENETICS,2013,45(12):1504-U140. |
| APA | Chen, JK.,Guo, L.,Zhang, L.,Wu, HY.,Yang, JQ.,...&Pei, DQ.(2013).Vitamin C modulates TET1 function during somatic cell reprogramming.NATURE GENETICS,45(12),1504-U140. |
| MLA | Chen, JK,et al."Vitamin C modulates TET1 function during somatic cell reprogramming".NATURE GENETICS 45.12(2013):1504-U140. |
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