Let7a inhibits the growth of endometrial carcinoma cells by targeting Aurora-B
文献类型：期刊论文
| 作者 | Liu, P; Qi, MY; Ma, CB; Lao, GY; Liu, Y; Liu, Y; Liu, YZ |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2013 |
| 卷号 | 587期号:16页码:2523-2529 |
| 关键词 | Endometrial carcinoma cell Targeting Aurora-B MicroRNA Let-7a |
| 通讯作者 | Ma, CB (reprint author), Changning Matern & Infant Hlth Hosp, Dept Gynecol, Shanghai, Peoples R China.,cbma1966@live.cn |
| 英文摘要 | MicroRNAs negatively regulate target gene expression at the post-transcriptional level during carcinogenesis. Recent advances revealed that the expression levels of several miRNAs are up- or down-regulated in endomenial carcinoma (EC). Here we identify dysregulated miRNAs in EC and we elucidate the essential role of let-7a. The expression of 86 miRNAs in EC was found to be different from adjacent normal endometrial tissues. Moreover, miR-let-7 members are down-regulated in EC and let-7 miRNAs are highly associated with endometrial cancer. A functional investigation revealed that let-7a suppressed proliferation of HeLa cells by targeting Aurora-B. Let-7a also antagonizes Aurora-B functions in promoting carcinoma cell proliferation by down-regulating Aurora-B protein level. Let-7a could be applied for gene therapy against endometrial carcinogenesis. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | LET-7 MICRORNA FAMILY ; CANCER CELLS ; EXPRESSION ; TUMORIGENESIS ; ONCOGENE ; ADENOCARCINOMA ; SUPPRESSOR ; REPRESSES ; PROGNOSIS ; PROFILES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000323458400007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/455]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, P,Qi, MY,Ma, CB,et al. Let7a inhibits the growth of endometrial carcinoma cells by targeting Aurora-B[J]. FEBS LETTERS,2013,587(16):2523-2529. |
| APA | Liu, P.,Qi, MY.,Ma, CB.,Lao, GY.,Liu, Y.,...&Liu, YZ.(2013).Let7a inhibits the growth of endometrial carcinoma cells by targeting Aurora-B.FEBS LETTERS,587(16),2523-2529. |
| MLA | Liu, P,et al."Let7a inhibits the growth of endometrial carcinoma cells by targeting Aurora-B".FEBS LETTERS 587.16(2013):2523-2529. |
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