Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling
文献类型：期刊论文
| 作者 | Yang, XF; Mao, FF; Lv, XD; Zhang, Z; Fu, L; Lu, Y; Wu, WQ; Zhou, ZC; Zhang, L; Zhao, Y |
| 刊名 | JOURNAL OF CELL SCIENCE
 |
| 出版日期 | 2013 |
| 卷号 | 126期号:18页码:4230-4238 |
| 关键词 | Drosophila Hedgehog Smoothened Trafficking Vps36 |
| 通讯作者 | Zhao, Y (reprint author), Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,rayzhang@sibcb.ac.cn ; yunzhao@sibcb.ac.cn |
| 英文摘要 | The hedgehog (Hh) signaling pathway plays a very important role in metazoan development by controlling pattern formation. Malfunction of the Hh signaling pathway leads to numerous serious human diseases, including congenital disorders and cancers. The seven-transmembrane domain protein Smoothened (Smo) is a key transducer of the Hh signaling pathway, and mediates the graded Hh signal across the cell plasma membrane, thereby inducing the proper expression of downstream genes. Smo accumulation on the cell plasma membrane is regulated by its C-tail phosphorylation and the graded Hh signal. The inhibitory mechanism for Smo membrane accumulation in the absence of Hh, however, is still largely unknown. Here, we report that Vps36 of the ESCRT-II complex regulates Smo trafficking between the cytosol and plasma membrane by specifically recognizing the ubiquitin signal on Smo in the absence of Hh. Furthermore, in the absence of Hh, Smo is ubiquitylated on its cytoplasmic part, including its internal loops and C-tail. Taken together, our data suggest that the ESCRT-II complex, especially Vps36, has a special role in controlling Hh signaling by targeting the membrane protein Smo for its trafficking in the absence of Hh, thereby regulating Hh signaling activity. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | ENDOSOME-ASSOCIATED COMPLEX ; ESCRT-II ; MULTIVESICULAR-BODY ; UBIQUITIN RECOGNITION ; CUBITUS-INTERRUPTUS ; PATHWAY ACTIVATION ; EAP45-GLUE DOMAIN ; STRUCTURAL BASIS ; SORTING COMPLEX ; DOWN-REGULATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000324380700016 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/458]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yang, XF,Mao, FF,Lv, XD,et al. Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling[J]. JOURNAL OF CELL SCIENCE,2013,126(18):4230-4238. |
| APA | Yang, XF.,Mao, FF.,Lv, XD.,Zhang, Z.,Fu, L.,...&Zhao, Y.(2013).Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling.JOURNAL OF CELL SCIENCE,126(18),4230-4238. |
| MLA | Yang, XF,et al."Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling".JOURNAL OF CELL SCIENCE 126.18(2013):4230-4238. |
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