Location of transient ectodermal progenitor potential in mouse development
文献类型：期刊论文
| 作者 | Li, LY; Liu, C; Biechele, S; Zhu, QQ; Song, L; Lanner, F; Jing, NH; Rossant, J |
| 刊名 | DEVELOPMENT
 |
| 出版日期 | 2013 |
| 卷号 | 140期号:22页码:4533-4543 |
| 关键词 | Ectoderm BMP4 Epidermis Nodal |
| 通讯作者 | Rossant, J (reprint author), Hosp Sick Children, Res Inst, Program Dev & Stem Cell Biol, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.,janet.rossant@sickkids.ca |
| 英文摘要 | Ectoderm is one of the three classic germ layers in the early mouse embryo, with the capacity to develop into both the central nervous system and epidermis. Because it is a transient phase of development with few molecular markers, the early ectoderm is the least understood germ layer in mouse embryonic development. In this work, we studied the differentiation potential of isolated ectoderm tissue in response to BMP signaling at various developmental stages ( E6.5, E7.0 and E7.5), and identified a transient region in the anteriorproximal side of the embryo at E7.0 that possesses the ability to become neural or epidermal ectoderm in response to the absence or presence of BMP4, respectively. Furthermore, we demonstrated that inhibition of Nodal signaling could direct the pluripotent E6.5 epiblast cells towards ectoderm lineages during differentiation in explants in vitro. Our work not only improves our understanding of ectodermal layer development in early embryos, but also provides a framework for regenerative differentiation towards ectodermal tissues. |
| 学科主题 | Developmental Biology |
| 类目[WOS] | Developmental Biology |
| 关键词[WOS] | EMBRYONIC STEM-CELLS ; ANTERIOR NEURAL PLATE ; GERM LAYER FORMATION ; EPIBLAST CELLS ; NEURONAL DIFFERENTIATION ; MORPHOGENETIC MOVEMENT ; VERTEBRATE EMBRYOS ; SIGNALING PATHWAYS ; FATE DECISIONS ; BODY PLAN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000326681900009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/467]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, LY,Liu, C,Biechele, S,et al. Location of transient ectodermal progenitor potential in mouse development[J]. DEVELOPMENT,2013,140(22):4533-4543. |
| APA | Li, LY.,Liu, C.,Biechele, S.,Zhu, QQ.,Song, L.,...&Rossant, J.(2013).Location of transient ectodermal progenitor potential in mouse development.DEVELOPMENT,140(22),4533-4543. |
| MLA | Li, LY,et al."Location of transient ectodermal progenitor potential in mouse development".DEVELOPMENT 140.22(2013):4533-4543. |
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