White Spot Syndrome Virus IE1 and WSV056 Modulate the G(1)/S Transition by Binding to the Host Retinoblastoma Protein
文献类型：期刊论文
| 作者 | Ran, XZ; Bian, XF; Ji, YC; Yan, XM; Yang, F; Li, F |
| 刊名 | JOURNAL OF VIROLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 87期号:23页码:12576-12582 |
| 通讯作者 | Li, F (reprint author), Third Inst Oceanog, State Key Lab Breeding Base Marine Genet Resource, Key Lab Marine Genet Resources State Ocean Adm, Xiamen, Peoples R China.,lifang_87@163.com |
| 英文摘要 | DNA viruses often target cellular proteins to modulate host cell cycles and facilitate viral genome replication. However, whether proliferation of white spot syndrome virus (WSSV) requires regulation of the host cell cycle remains unclear. In the present study, we show that two WSSV paralogs, IE1 and WSV056, can interact with Litopenaeus vannamei retinoblastoma (Rb)-like protein (lv-RBL) through the conserved LxCxE motif. Further investigation revealed that IE1 and WSV056 could also bind to Drosophila retinoblastoma family protein 1 (RBF1) in a manner similar to how they bind to lv-RBL. Using the Drosophila RBF-E2F pathway as a model system, we demonstrated that both IE1 and WSV056 could sequester RBF1 from Drosophila E2F transcription factor 1 (E2F1) and subsequently activate E2F1 to stimulate the G(1)/S transition. Our findings provide the first evidence that WSSV may regulate cell cycle progression by targeting the Rb-E2F pathway. |
| 学科主题 | Virology |
| 类目[WOS] | Virology |
| 关键词[WOS] | IMMEDIATE-EARLY GENES ; LYTIC REPLICATION ; CELL-CYCLE ; TUMOR-SUPPRESSOR ; GENOME SEQUENCE ; WSSV GENE ; SHRIMP ; IDENTIFICATION ; DROSOPHILA ; POLYMERASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000327183800007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/469]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Ran, XZ,Bian, XF,Ji, YC,et al. White Spot Syndrome Virus IE1 and WSV056 Modulate the G(1)/S Transition by Binding to the Host Retinoblastoma Protein[J]. JOURNAL OF VIROLOGY,2013,87(23):12576-12582. |
| APA | Ran, XZ,Bian, XF,Ji, YC,Yan, XM,Yang, F,&Li, F.(2013).White Spot Syndrome Virus IE1 and WSV056 Modulate the G(1)/S Transition by Binding to the Host Retinoblastoma Protein.JOURNAL OF VIROLOGY,87(23),12576-12582. |
| MLA | Ran, XZ,et al."White Spot Syndrome Virus IE1 and WSV056 Modulate the G(1)/S Transition by Binding to the Host Retinoblastoma Protein".JOURNAL OF VIROLOGY 87.23(2013):12576-12582. |
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