Activation of Aryl Hydrocarbon Receptor (AhR) by Tranilast, an Anti-allergy Drug, Promotes miR-302 Expression and Cell Reprogramming
文献类型：期刊论文
| 作者 | Hu, WX; Zhao, J; Pei, G |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2013 |
| 卷号 | 288期号:32页码:22972-22984 |
| 通讯作者 | Pei, G (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,gpei@sibs.ac.cn |
| 英文摘要 | MiR-302 has been shown to regulate pluripotency genes and help somatic cell reprogramming. Thus, promotion of endogenous miR-302 expression could be a desirable way to facilitate cell reprogramming. By using a luciferase reporter system of the miR-302 promoter, we screened and found that an anti-allergy drug, tranilast, could significantly promote miR-302 expression. Further experiments revealed that two aryl hydrocarbon receptor (AhR) binding motifs on the miR-302 promoter are critical and that activation of AhR is required for tranilast-induced miR-302 expression. Consistently, not only tranilast but other AhR agonists promoted miR-302 expression. Furthermore, the activation of AhR facilitated cell reprogramming in a miR-302-dependent way. These results elucidate that miR-302 expression can be regulated by AhR and thus provide a strategy for promoting somatic cell reprogramming by AhR ligands. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | PLURIPOTENT STEM-CELLS ; HUMAN SOMATIC-CELLS ; SMALL-MOLECULE COMPOUNDS ; POLYCISTRONIC VECTOR ; SIGNALING PATHWAY ; MICRORNAS ; GENERATION ; MOUSE ; INDUCTION ; CLUSTER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330598200008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/473]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Hu, WX,Zhao, J,Pei, G. Activation of Aryl Hydrocarbon Receptor (AhR) by Tranilast, an Anti-allergy Drug, Promotes miR-302 Expression and Cell Reprogramming[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2013,288(32):22972-22984. |
| APA | Hu, WX,Zhao, J,&Pei, G.(2013).Activation of Aryl Hydrocarbon Receptor (AhR) by Tranilast, an Anti-allergy Drug, Promotes miR-302 Expression and Cell Reprogramming.JOURNAL OF BIOLOGICAL CHEMISTRY,288(32),22972-22984. |
| MLA | Hu, WX,et al."Activation of Aryl Hydrocarbon Receptor (AhR) by Tranilast, an Anti-allergy Drug, Promotes miR-302 Expression and Cell Reprogramming".JOURNAL OF BIOLOGICAL CHEMISTRY 288.32(2013):22972-22984. |
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