NEDD8 Ultimate Buster-1 Long (NUB1L) Protein Promotes Transfer of NEDD8 to Proteasome for Degradation through the P97(UFD1/NPL4) Complex
文献类型：期刊论文
| 作者 | Liu, S; Yang, H; Zhao, J; Zhang, YH; Song, AX; Hu, HY |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2013 |
| 卷号 | 288期号:43页码:31339-31349 |
| 通讯作者 | Hu, HY (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,hyhu@sibcb.ac.cn |
| 英文摘要 | The NEDD8 protein and neddylation levels in cells are modulated by NUB1L or NUB1 through proteasomal degradation, but the underlying molecular mechanism is not well understood. Here, we report that NUB1L down-regulated the protein levels of NEDD8 and neddylation through specifically recognizing NEDD8 and P97/VCP. NUB1L directly interacted with NEDD8, but not with ubiquitin, on the key residue Asn-51 of NEDD8 and with P97/VCP on its positively charged VCP binding motif. In coordination with the P97-UFD1-NPL4 complex (P97(UFD1/NPL4)), NUB1L promotes transfer of NEDD8 to proteasome for degradation. This mechanism is also exemplified by the canonical neddylation of cullin 1 for SCF (SKP1-cullin1-F-box) ubiquitin E3 ligases that is exquisitely regulated by the turnover of NEDD8. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | UBIQUITIN-LIKE PROTEIN ; LEBER CONGENITAL AMAUROSIS ; P97 AAA ATPASE ; SYNPHILIN-1-BINDING PROTEIN ; CONFORMATIONAL-CHANGES ; BODY DISEASE ; BINDING ; LIGASES ; SYSTEM ; FAT10 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330778900050 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/478]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, S,Yang, H,Zhao, J,et al. NEDD8 Ultimate Buster-1 Long (NUB1L) Protein Promotes Transfer of NEDD8 to Proteasome for Degradation through the P97(UFD1/NPL4) Complex[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2013,288(43):31339-31349. |
| APA | Liu, S,Yang, H,Zhao, J,Zhang, YH,Song, AX,&Hu, HY.(2013).NEDD8 Ultimate Buster-1 Long (NUB1L) Protein Promotes Transfer of NEDD8 to Proteasome for Degradation through the P97(UFD1/NPL4) Complex.JOURNAL OF BIOLOGICAL CHEMISTRY,288(43),31339-31349. |
| MLA | Liu, S,et al."NEDD8 Ultimate Buster-1 Long (NUB1L) Protein Promotes Transfer of NEDD8 to Proteasome for Degradation through the P97(UFD1/NPL4) Complex".JOURNAL OF BIOLOGICAL CHEMISTRY 288.43(2013):31339-31349. |
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