Preparation and properties of g-TTCP/PBS nanocomposites and its in vitro biocompatibility assay
文献类型：期刊论文
| 作者 | Fan, RR; Zhou, LX; Song, W; Li, DX; Zhang, DM; Ye, R; Zheng, Y; Guo, G |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2013 |
| 卷号 | 59期号:1页码:227-234 |
| 关键词 | Surface grafting Tetracalcium phosphate Poly(butylene succinate) Osteoblasts |
| 通讯作者 | Guo, G (reprint author), Sichuan Univ, West China Hosp, West China Med Sch, State Key Lab Biotherapy, Chengdu 610041, Peoples R China.,guogang@scu.edu.cn |
| 英文摘要 | In an effort to decrease the aggregation of tetracalcium phosphate (TTCP, Ca-4(PO4)(2)O) in composites and develop better bone substitute materials, a series of poly(L-lactic acid) (PLLA)-grafted ITCP (g-TTCP) particles were prepared by a ring-opening polymerization with L-lactide (the monomer for synthesizing PLLA) in the presence of catalyst stannous octoate [Sn(Oct)(2)]. The g-TTCP/poly(1,4-butylene succinate) (PBS) composites with the different g-TTCP contents were prepared via melting processing. The bonding between the PLLA and the TTCP particles was analyzed by FTIR, TG, H-1 NMR and XPS. The results confirmed that the PLLA was grafted on the surface of the TTCP particles. Time-dependent phase monitoring indicated that the g-TTCP had enhanced dispersion in the PBS solution. Water contact angle measurement and cell culture were also used to investigate the properties of the g-TTCP/PBS composites. The g-TTCP in composites provided more favorable environments for rat osteoblast to attach and grow on the surface of the g-TTCP/PBS composites. Cell proliferated well in the extracted solution of the g-TTCP/PBS composites with different g-TTCP content, and there was no necrotic or suspended cells appeared. (C) 2013 Elsevier B.V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | BIODEGRADABLE POLY(BUTYLENE SUCCINATE) ; SURFACE MODIFICATION ; TRICALCIUM PHOSPHATE ; COMPOSITE SCAFFOLDS ; BONE ; HYDROXYAPATITE ; OSTEOBLAST ; POLYMERS ; ADHESION ; COMPATIBILITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000321229000032 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/513]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Fan, RR,Zhou, LX,Song, W,et al. Preparation and properties of g-TTCP/PBS nanocomposites and its in vitro biocompatibility assay[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2013,59(1):227-234. |
| APA | Fan, RR.,Zhou, LX.,Song, W.,Li, DX.,Zhang, DM.,...&Guo, G.(2013).Preparation and properties of g-TTCP/PBS nanocomposites and its in vitro biocompatibility assay.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,59(1),227-234. |
| MLA | Fan, RR,et al."Preparation and properties of g-TTCP/PBS nanocomposites and its in vitro biocompatibility assay".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 59.1(2013):227-234. |
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