Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum
文献类型：期刊论文
| 作者 | Kong, LW; Choi, RCY; Tsim, KWK; Jing, NH; Nakayama, DK; Wang, ZB |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2013 |
| 卷号 | 543期号:1页码:22-26 |
| 关键词 | rKirre IgSF CAM Cerebellum Granule cell Purkinje cell Development |
| 通讯作者 | Wang, ZB (reprint author), Mercer Univ, Sch Med, Dept Surg, 1550 Coll St, Macon, GA 31207 USA.,wang_z@mercer.edu |
| 英文摘要 | Immunoglobulin superfamily (IgSF) molecules are actively involved in cell-cell adhesion, neuronal migration, axonal guidance and synapse formation in the nervous system. Kirre, as a member of this family, has been implicated in mammalian neuronal differentiation and development. Although the distribution of rKirre (a rat homologue of Drosophila Kirre) mRNA was previously analyzed in adult rat cerebellum by in situ hybridization, the expression levels of transcript and protein were not well studied. Here, we showed that the expressions of rKirre mRNA and protein significantly increased during postnatal development of rat cerebellum. rKirre mRNA was mainly expressed in the granular layers and Purkinje cell layer in the developing cerebellum, revealing a possible involvement of rKirre in granule cell migration and Purkinje cell development. An essential relationship between rKirre and Purkinje cells was implied by the co-localization of rKirre and NF-200 on the cell bodies of Purkinje cells. These results suggest that rKirre may play a potential role in postnatal developing rat cerebellum. (C) 2013 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | RECEPTOR TYROSINE KINASE ; CELL-ADHESION MOLECULES ; IMMUNOGLOBULIN SUPERFAMILY ; MYOBLAST FUSION ; DROSOPHILA-MELANOGASTER ; CONTACTIN/F3 SUBGROUP ; PURKINJE-CELLS ; MOUSE-BRAIN ; NEPHRIN ; PROTEIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000319646000005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/516]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Kong, LW,Choi, RCY,Tsim, KWK,et al. Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum[J]. NEUROSCIENCE LETTERS,2013,543(1):22-26. |
| APA | Kong, LW,Choi, RCY,Tsim, KWK,Jing, NH,Nakayama, DK,&Wang, ZB.(2013).Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum.NEUROSCIENCE LETTERS,543(1),22-26. |
| MLA | Kong, LW,et al."Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum".NEUROSCIENCE LETTERS 543.1(2013):22-26. |
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