中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum

文献类型:期刊论文

作者Kong, LW; Choi, RCY; Tsim, KWK; Jing, NH; Nakayama, DK; Wang, ZB
刊名NEUROSCIENCE LETTERS
出版日期2013
卷号543期号:1页码:22-26
关键词rKirre IgSF CAM Cerebellum Granule cell Purkinje cell Development
通讯作者Wang, ZB (reprint author), Mercer Univ, Sch Med, Dept Surg, 1550 Coll St, Macon, GA 31207 USA.,wang_z@mercer.edu
英文摘要Immunoglobulin superfamily (IgSF) molecules are actively involved in cell-cell adhesion, neuronal migration, axonal guidance and synapse formation in the nervous system. Kirre, as a member of this family, has been implicated in mammalian neuronal differentiation and development. Although the distribution of rKirre (a rat homologue of Drosophila Kirre) mRNA was previously analyzed in adult rat cerebellum by in situ hybridization, the expression levels of transcript and protein were not well studied. Here, we showed that the expressions of rKirre mRNA and protein significantly increased during postnatal development of rat cerebellum. rKirre mRNA was mainly expressed in the granular layers and Purkinje cell layer in the developing cerebellum, revealing a possible involvement of rKirre in granule cell migration and Purkinje cell development. An essential relationship between rKirre and Purkinje cells was implied by the co-localization of rKirre and NF-200 on the cell bodies of Purkinje cells. These results suggest that rKirre may play a potential role in postnatal developing rat cerebellum. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
学科主题Neurosciences & Neurology
类目[WOS]Neurosciences
关键词[WOS]RECEPTOR TYROSINE KINASE ; CELL-ADHESION MOLECULES ; IMMUNOGLOBULIN SUPERFAMILY ; MYOBLAST FUSION ; DROSOPHILA-MELANOGASTER ; CONTACTIN/F3 SUBGROUP ; PURKINJE-CELLS ; MOUSE-BRAIN ; NEPHRIN ; PROTEIN
收录类别SCI
语种英语
WOS记录号WOS:000319646000005
版本出版稿
源URL[http://202.127.25.143/handle/331003/516]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
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GB/T 7714
Kong, LW,Choi, RCY,Tsim, KWK,et al. Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum[J]. NEUROSCIENCE LETTERS,2013,543(1):22-26.
APA Kong, LW,Choi, RCY,Tsim, KWK,Jing, NH,Nakayama, DK,&Wang, ZB.(2013).Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum.NEUROSCIENCE LETTERS,543(1),22-26.
MLA Kong, LW,et al."Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum".NEUROSCIENCE LETTERS 543.1(2013):22-26.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

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