Cancer cell growth suppression by a 62nt AU-rich RNA from C/EBP beta 3 ' UTR through competitive binding with HuR
文献类型：期刊论文
| 作者 | Sun, DQ; Wang, Y; Liu, DG |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2012 |
| 卷号 | 426期号:1页码:122-128 |
| 关键词 | Distinct AU-rich RNA C/EBP beta 3 ' UTR Tumor suppression HuR Competitive binding |
| 通讯作者 | Liu, DG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,dgliu@sibs.ac.cn |
| 英文摘要 | AU-rich elements are functional motifs in the 3'untranslated region of mRNA and are binding sites for the RNA binding protein HuR, an mRNA stabilizer and translation enhancer implicated in carcinogenesis. It is not clear whether, and, if so, how the AU-rich elements function in cells when they are separated from their mRNA and form an independent RNA species. Here, we show that a short RNA with AU-rich elements derived from C/EBP beta 3'UTR suppressed growth in a human liver cancer cell line. It specifically bound HuR, and it competed with C/EBP beta mRNA in order to bind to HuR. Our results provide evidence that the cancer cell growth suppression by this 62nt RNA containing AU-rich elements may be due to competitive binding to HuR. This work may open new options for the development of novel anti-cancer drugs. (C) 2012 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | 3' UNTRANSLATED REGION ; TUMOR SUPPRESSION ; MESSENGER-RNAS ; BREAST-CANCER ; ELEMENTS ; DEGRADATION ; EXPRESSION ; REVERSION ; MECHANISM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000309312300022 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/528]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Sun, DQ,Wang, Y,Liu, DG. Cancer cell growth suppression by a 62nt AU-rich RNA from C/EBP beta 3 ' UTR through competitive binding with HuR[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2012,426(1):122-128. |
| APA | Sun, DQ,Wang, Y,&Liu, DG.(2012).Cancer cell growth suppression by a 62nt AU-rich RNA from C/EBP beta 3 ' UTR through competitive binding with HuR.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,426(1),122-128. |
| MLA | Sun, DQ,et al."Cancer cell growth suppression by a 62nt AU-rich RNA from C/EBP beta 3 ' UTR through competitive binding with HuR".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 426.1(2012):122-128. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。